Nogo-A蛋白及调控轴突再生作用研究进展  

Nogo-A Protein and Inhibitory Functions on Axonal Regeneration

作　　者：孟瑶 王颖[1] MENG Yao;WANG Ying(School of Basic Medical Sciences,Capital Medical University,Beijing 100069,China)

机构地区：[1]首都医科大学基础医学院,北京100069

出　　处：《神经损伤与功能重建》2024年第3期151-156,共6页Neural Injury and Functional Reconstruction

基　　金：国家重点研发计划(No.2021YFC2400801);首都医科大学本科生科研项目(No.7NZDS2022)。

摘　　要：中枢神经系统损伤产生的抑制性微环境是神经再生困难的重要原因,其中Nogo-A蛋白是抑制轴突再生的关键因子,其结构域以片段形式通过不同途径释放到细胞外,与受体NgR1、PirB、S1PR2或HSPG相结合,激活多种信号通路调控细胞凋亡、运动以及细胞骨架蛋白聚合,引起细胞骨架解聚、生长锥塌陷,抑制神经元轴突生长。本文对Nogo-A蛋白的结构、受体和抑制轴突再生作用机制的研究进展进行综述。Nogo-A plays a crucial role in the inhibitory microenvironment in the central nervous system and is considered to be the most important barrier for neural regeneration.This review discusses the different domains,receptors and following signal pathways of Nogo-A,as well as their roles in apoptosis,motility and cytoskeleton polymerization,thereby inducing growth cone collapse and ultimately inhibiting axon regrowth.Therefore,Nogo-A would be promising targets for neural regeneration.

关 键 词：NOGO-A蛋白 受体 信号通路 轴突再生 

分 类 号：R741[医药卫生—神经病学与精神病学] R741.02[医药卫生—临床医学]