鬼臼毒素类药物的生物合成及药理作用的研究现状  

Research Status of Biosynthesis and Pharmacological Effects of Podophyllotoxin Drugss

作　　者：郭源辉 申佰轩 韩霜 李晶晶[3] 段佳佳 刘传鑫 Guo Yuanhui;Shen Baixuan;Han Shuang;Li Jingjing;Duan Jiajia;Liu Chuanxin(Endocrine and Metabolic Disease Center,First Affiliated Hospital,College of Clinical Medicine of Henan University of Science and Technology,Rare Disease Laboratory of Henan,Luoyang 471003,China;School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 100029,China;Clinical Medical College of Henan University of Science and Technology,Obstetrics and Gynecology Department of the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471003,China;Clinical Medical College of Henan University of Science and Technology,Clinical Laboratory Department of the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471003,China)

机构地区：[1]河南科技大学临床医学院,河南科技大学第一附属医院内分泌代谢中心,河南省罕见病实验室,洛阳471003 [2]北京中医药大学中药学院,北京100029 [3]河南科技大学临床医学院,河南科技大学第一附属医院妇产科,洛阳471003 [4]河南科技大学临床医学院,河南科技大学第一附属医院检验科,洛阳471003

出　　处：《世界科学技术-中医药现代化》2023年第12期3785-3796,共12页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委员会青年科学基金项目(82204938):基于“毒理证据链”解析八角莲致肝损伤的“证-量-毒”关系与体内毒性传递路径,负责人:刘传鑫。

摘　　要：目的本文总结了鬼臼毒素类药物生物合成及其药理作用的研究进展,以期为该类药物的广泛应用提供参考。方法归纳了鬼臼毒素类药物的植物来源、化学结构、作用机理及合成途径,探讨了这些药物的药理、毒理特点和机制,并梳理了鬼臼毒素药物新剂型的研究进展。结果鬼臼毒素及其衍生物是中药八角莲、山荷叶及桃儿七等鬼臼属植物中的重要化学成分。该类药物天然来源较少,可通过化学及生物合成途径进行人工生产。鬼臼毒素类药物具有抗炎、抗肿瘤和抗病毒等药理作用,但其毒性作用对此类药物的临床使用有着限制,可通过运载体运送药物以达到减毒增效的目的,为此类药物的临床使用提供新途径。结论鬼臼毒素类药物具有广泛临床应用前景,未来将在抗炎、抗肿瘤和抗病毒等领域得到更多的研究和应用。Objective This paper summarizes the research progress of biosynthesis and pharmacological effects of podophyllotoxin drugs,in order to provide reference for the wide application of these drugs.Methods The plant source,chemical structure,action mechanism and synthesis pathway of podophyllotoxin drugs were summarized.The pharmacological and toxicological characteristics and mechanisms of these drugs were discussed,and the research progress of new dosage forms of podophyllotoxin drugs was reviewed.Results Podophyllotoxin and its derivatives are important chemical constituents in the plants of the podophyllum,such as Dysosma versipellis,Diphylleia sinensis,Sinopodophyllum hexandrum.This kind of drug has few natural sources and can be artificially produced through chemical and biosynthetic pathways.Podophyllotoxin drugs have pharmacological effects such as anti-inflammatory,anti-tumor and anti-virus,but their toxic effects need to be paid attention to.Drugs can be transported by carriers to reduce toxicity and increase effect.Conclusion Podophyllotoxin drugs have broad clinical application prospects,and will be further studied and applied in the fields of anti-inflammatory,anti-tumor and anti-virus in the future.

关 键 词：鬼臼毒素 鬼臼毒素类药物 人工合成 药理作用 毒理作用 鬼臼毒素新剂型 

分 类 号：R914.5[医药卫生—药物化学]