Gain deeper insights into traditional Chinese medicines using multidimensional chromatography combined with chemometric approaches  

作　　者：Xinyue Yang Pingping Zeng Jin Wen Chuanlin Wang Liangyuan Yao Min He 

机构地区：[1]Department of Pharmaceutical Engineering,School of Chemical Engineering,Xiangtan University,Xiangtan 411105,China [2]Hunan Qianjin Xiangjiang Pharmaceutical Joint Stock Co.,Ltd.,Zhuzhou 412000,China

出　　处：《Chinese Herbal Medicines》2024年第1期27-41,共15页中草药（英文版）

基　　金：This work is financially supported by the Hunan 2011 Collaborative Innovation Center of Chemical Engineering&Technology with Environmental Benignity and Effective Resource Utilization;Additional funding was provided by the Hunan Province Natural Science Fund(No.2020JJ4569 and 2023JJ60378);the Hunan Province College Students’Innovation and Entrepreneurship Training Program(No.S202110530044 and S202210530048).

摘　　要：Traditional Chinese medicines(TCMs)possess a rich historical background,unique theoretical framework,remarkable therapeutic efficacy,and abundant resources.However,the modernization and internationalization of TCMs have faced significant obstacles due to their diverse ingredients and unknown mechanisms.To gain deeper insights into the phytochemicals and ensure the quality control of TCMs,there is an urgent need to enhance analytical techniques.Currently,two-dimensional(2D)chromatography,which incorporates two independent separation mechanisms,demonstrates superior separation capabilities compared to the traditional one-dimensional(1D)separation system when analyzing TCMs samples.Over the past decade,new techniques have been continuously developed to gain actionable insights from complex samples.This review presents the recent advancements in the application of multidimensional chromatography for the quality evaluation of TCMs,encompassing 2D-gas chromatography(GC),2D-liquid chromatography(LC),as well as emerging three-dimensional(3D)-GC,3D-LC,and their associated data-processing approaches.These studies highlight the promising potential of multidimensional chromatographic separation for future phytochemical analysis.Nevertheless,the increased separation capability has resulted in higher-order data sets and greater demands for data-processing tools.Considering that multidimensional chromatography is still a relatively nascent research field,further hardware enhancements and the implementation of chemometric methods are necessary to foster its robust development.

关 键 词：CHEMOMETRICS multidimensional separation off-line two-dimensional liquid CHROMATOGRAPHY on-line two-dimensional liquid CHROMATOGRAPHY quality control traditional chinese medicines two-dimensional gas chromatography 

分 类 号：R284[医药卫生—中药学]