染色质重塑因子对哺乳动物配子发生及早期胚胎发育进程影响的研究进展  

Research progress on the effects of chromatin remodeling factors on mammalian gametogenesis and early embryonic development

作　　者：洪仁芸 梁元姣 Hong Renyun;Liang Yuanjiao(Department of Reproductive Medicine,Zhongda Hospital,Southeast University,Nanjing 210009,China)

机构地区：[1]东南大学附属中大医院生殖医学科,南京210009

出　　处：《中华生殖与避孕杂志》2024年第2期201-204,共4页Chinese Journal of Reproduction and Contraception

基　　金：东南大学附属中大医院人才引进基金项目(ZDYYZXKT2019001)。

摘　　要：真核生物中染色质重塑因子种类繁多,根据ATP酶和其他组成蛋白亚单位的不同大致可以分为四类:SWI/SNF、ISWI、CHD和INO80。不同的染色质重塑因子在不同的层面通过对染色质结构的改变来影响基因转录调控等,以确保细胞内各种生物学进程的准确运行。目前,关于染色质重塑因子在哺乳动物配子发生及早期胚胎发育过程中发挥作用的研究尚不普遍。本文将以四类染色质重塑因子为切入点对此进行简单综述,为深入了解染色质重塑因子在生殖发育等方面的功能提供理论依据。There are various types of chromatin remodeling factors in eukaryotes,which can be divided into four categories:SWI/SNF,ISWI,CHD and INO80,according to the differences of ATPase and other constituent protein subunits.These remodeling factors affect gene transcription regulation through changes in chromatin structure to ensure the accurate operation of various biological processes in cells.At present,the role of chromatin remodeling factors in mammalian gametogenesis and early embryonic development is not widely studied.In this paper,we will make a brief review to provide theoretical basis for further understanding of the functions about the chromatin remodeling factors in reproductive development.

关 键 词：染色质重塑因子 配子发生 早期胚胎发育 哺乳动物 

分 类 号：R394[医药卫生—医学遗传学]