人乳头瘤病毒疫苗的研究现状与展望  

The Status Quo and Prospects of Human Papillomavirus Vaccine

作　　者：卢林丽 方佳琦 阴建[1,2] 党乐 朱兰 LU Linli;FANG Jiaqi;YIN Jian;DANG Le;ZHU Lan(School of Population Medicine and Public Health,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China;National Clinical Research Center for Obstetric Gynecologic Disease,Department of Obstetrics and Gynecology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医学院群医学及公共卫生学院,北京100730 [2]国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院,北京100021 [3]国家妇产疾病临床医学研究中心,中国医学科学院北京协和医学院北京协和医院,北京100730

出　　处：《中国肿瘤》2024年第2期153-160,共8页China Cancer

基　　金：中国医学科学院医学与健康科技创新工程项目(2021-I2M-1-004);北京协和医院中央高水平医院临床科研专项项目(2022-PUMCH-D-003)。

摘　　要：宫颈癌严重危害女性生命健康,近年来针对宫颈癌的一系列预防手段不断被探索开发,其中,疫苗是消除宫颈癌的有效手段。预防性人乳头瘤病毒(human papillomavirus,HPV)疫苗可从根本上阻断HPV的传播,是消除宫颈癌的第一道防线,目前多个疫苗已上市并被广泛应用。针对逆转HPV持续感染和宫颈病变的治疗性HPV疫苗的研发及验证研究正在陆续开展。疫苗对于宫颈癌的防治至关重要,全文综述HPV疫苗的研究进展。Cervical cancer is a serious threat to life and health of women worldwide.A series of approaches for prevention and control of cervical cancer have been explored and developed,among which the vaccine is considered an effective means to prevent the occurrence of cervical cancer.Preventive human papillomavirus(HPV)vaccine can block the transmission of HPV virus,which is the first line of defense to eliminate cervical cancer;and several vaccines have been marketed and widely used.Meanwhile,the development of therapeutic HPV vaccines aimed at reversing persistent HPV infection and cervical lesions is now underway.This paper reviews the research of developments of HPV vaccines for prevention and treatment of cervical cancer.

关 键 词：人乳头瘤病毒 宫颈癌 预防性疫苗 治疗性疫苗 

分 类 号：R730.1[医药卫生—肿瘤] R737.3[医药卫生—临床医学]