在大骨节病区示范点采取预防措施防治大骨节病效果研究  

Research of effects on the preventive measures for prevention and control o Kashin-Beck disease at the Kaschin-Beck disease demonstration site

作　　者：李小颖[1] 王旭东[2] 安小芳[3] 董思源 凌丹[5] 杜小平 王治伦 陈群 LI Xiaoying;WANG Xudong;AN Xiaofang;DONG Siyuan;LING Dan;DU Xiaoping;WANG Zhilun;CHEN Qun(Hospital of Xi'an Jiaotong University,Xi'an Jiaotong University,Xi'an,Shaanxi 710061,China;不详)

机构地区：[1]西安交通大学医院,陕西710061 [2]西安建筑科技大学 [3]西安交通大学第一附属医院 [4]西安交通大学医学部 [5]西安交通大学第二附属医院 [6]安康市富硒产品研发中心 [7]卫计委地方病与微量元素重点实验室,西安交通大学医学部公共卫生学院

出　　处：《中国地方病防治》2024年第1期1-4,共4页Chinese Journal of Control of Endemic Diseases

基　　金：国家自然科学基金项目(81673115,82073496);科技部国家科技惠民计划项目(2012GS610101);陕西省卫生厅科研项目(2018D050);陕西省国际合作项目(2020KW-057);农业农村部富硒产品开发与质量控制重点实验室/富硒食品开发国家地方联合工程实验室开放课题资助项目(Se-2023C02)。

摘　　要：目的观察陕西省旬邑县大骨节病病区7~12岁儿童采用补硒及主食粮干燥措施预防大骨节病的效果。方法在病区采用补硒及主食粮干燥措施,并分别在预防措施实施前后的2014年和2016年对病区儿童拍右手X线片,采集头发、小麦和水样,以西安市健康体检儿童为非病区对照,采用双道原子荧光和ELISA法等测定硒和T-2毒素含量及粮食含水率。结果2014年旬邑县7~12岁儿童大骨节病X线检出率为9.9%,为大骨节病轻病区,小麦硒含量为7.03±5.94ng/g,发硒含量为0.24±0.07μg/g,水硒含量为0.51±0.27ng/mL。非病区对照小麦硒含量为22.43±6.38ng/g,发硒含量为0.62±0.13μg/g,水硒含量为0.75±0.11ng/mL。病区小麦T-2毒素含量为206μg/g,小麦含水率为16%。结果表明,旬邑县7~12岁儿童发硒含量显著低于西安地区儿童,小麦硒含量显著低于西安地区,采用补硒及主食粮干燥后,2016年预防组儿童发硒含量显著增加,粮食T-2毒素含量为96ng/g,含水率为12%,均达到国家标准。结论旬邑县大骨节病病区外环境处于低硒状态,大骨节病X线检出率较高,儿童补硒及采取主食粮干燥预防后,发硒含量显著增加,无新发病例。Objective To observe the effect of selenium supplement and drying of staple food on prevention of Kashin-Beck disease among children aged 7-12 years old in Xunyi county,Shaanxi Province.Methods Selenium supplementation and staple food drying measures were adopted in Xunyi county.In 2014(before the implementation of preventive measures)and 2016(2 years after the implementation of preventive measures),children aged 7-12 years old from Xunyi county were taken right-hand X-ray films and samples of food,water and hair.Results The X-ray prevalence of KBD in 7-12 years old children in Xunyi County in 2014 was 9.9%.The selenium contents of flour,hair and water were 7.03±5.94 ng/g,0.24±0.07μg/g and 0.51±0.27 ng/mL respectively while 22.43±6.38 ng/g,0.62±0.13μg/g and 0.75±0.11 ng/mL in control group.The content of T-2 toxin in wheat was 206 ng/g,and the moisture content of wheat was 16%in Xunyi County.The results have been shown that the hair selenium content of children aged 7-12 in Xunyi County was significantly lower than that of children in Xi'an area,and the content of selenium in wheat in Xunyi County was significantly lower than that of in Xi'an area.After selenium supple-mentation and staple food drying for prevention,the selenium content of hair was increased significantly,the content of T-2 toxin(96 ng/g)and ratio of moisture in grain(12%)reached the national standard in prevention group in 2016.Conclusion The environment of Xunyi County is in a state of low selenium,and the prevalence of KBD by X-ray examination is still high.The content of selenium for children increase significantly after taking selenium supplements and staple food drying prevention,and therefore no new cases are reported.

关 键 词：大骨节病 硒 T-2毒素 主食 

分 类 号：R684.1[医药卫生—骨科学]