围绝经期睡眠障碍的发病机制  

Pathogenesis of Perimenopausal Sleep Disorders

作　　者：宗嬿 陈宜爽 徐莲薇(审校)[1] ZONG Yan;CHEN Yi-shuang;XU Lian-wei(Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)

机构地区：[1]上海中医药大学附属龙华医院,200032

出　　处：《国际生殖健康／计划生育杂志》2024年第2期166-171,共6页Journal of International Reproductive Health/Family Planning

基　　金：国家自然科学基金(82174427);上海申康医院发展中心促进市级医院临床技能与临床创新三年行动计划(SHDC 2020CR2050B)。

摘　　要：围绝经期是女性生命过程中必经的特殊时期,该时期女性生殖机能下降,体内激素水平产生波动,出现一系列临床症候群,睡眠障碍即是其中的常见症状之一。围绝经期睡眠障碍的相关因素及其发病机制,主要与激素变化、血管舒缩症状、神经递质失衡等因素有关,也与焦虑抑郁状态、情绪障碍、睡眠觉醒周期、褪黑素分泌下降、呼吸暂停和低通气、不宁腿综合征等有关,衰老本身和代谢问题也起一定作用。基于近年来较为主流的发病因素,从不同角度分析探讨了围绝经期睡眠障碍的发病机制研究进展。Perimenopausal period is a special period in the life process of the female.During this period,the reproductive function of women declines and the levels of hormones fluctuate,leading to a series of clinical symptoms.Sleep disorder is one of the common symptoms.The factors and pathogenesis of perimenopausal sleep disorders are mainly related to hormonal changes,vasomotor symptoms and neurotransmitter unbalance.It is also related to anxiety and depression,emotional disorder,sleep-wake cycle,down-regulation of melatonin,apnea and hypopnea,restless leg syndrome,etc.Aging itself and metabolic problems also play a role.In this article,we discuss the related factors and pathogenesis of perimenopausal sleep disorders from the different perspectives.

关 键 词：围绝经期 睡眠障碍 雌激素类 多道睡眠描记术 睡眠呼吸暂停综合征 

分 类 号：R740[医药卫生—神经病学与精神病学]