基于中西医临床病证特点的黄疸动物模型分析  

Analysis of Jaundice Animal Model:Based on the Clinical Syndrome Characteristics in Traditional Chinese and Western Medicine*

作　　者：田单单 王灿[1] 苗明三[1] TIAN Dandan;WANG Can;MIAO Mingsan(School of Traditional Chinese Medicine,Henan University of Chinese Medicine,Zhengzhou 450046)

机构地区：[1]河南中医药大学中医药科学院,郑州450046

出　　处：《中药药理与临床》2024年第1期93-96,128,共5页Pharmacology and Clinics of Chinese Materia Medica

基　　金：国家中医药管理局标准化项目(编号:GZY-FJS-2020-219);河南省重大公益专项(编号:201300310100);河南省中医药科学研究专项课题(编号:20-21ZYZD02);河南省高等学校重点科研项目(编号:22B36008);中原学者工作站项目(编号:224400510011)。

摘　　要：近年来黄疸的患病率逐渐升高,病情越来越复杂,对治疗方法和治疗药物的需求越发强烈,构建高度复制疾病的动物模型是研究疾病的必由之路。本文主要基于中西医临床病证特点,参照临床诊断标准,对现有黄疸动物模型进行整理分析,拟定黄疸中西医诊断标准,并对吻合度进行评价。结果显示,现有动物模型主要有梗阻性黄疸、阴黄证、阳黄证、肝细胞性黄疸、溶血性黄疸、等。西医模型较多,中医证候模型较少。西医治疗黄疸处于早期临床实践阶段,治疗药物和方法较少,且存在副作用;中医治疗黄疸效果较好,药物温和,对机体刺激性较小为首选方法。未来应该完善中医证候动物模型,为新药的研发、疾病早期防治,提供一定的理论基础。In recent years,the prevalence of jaundice has been on the rise as the disease becomes more complex,which poses a challenge to the treatment.An accurate animal model is the key to the study of this disease.Based on the clinical symptoms of this disease in traditional Chinese medicine(TCM)and western medicine as well as the clinical diagnostic criteria,this study analyzed the currently available animal models of jaundice,designed the diagnostic criteria in traditional Chinese and western medicine,and evaluated the match degree.The results showed that the existing animal models mainly include obstructive jaundice,jaundice with Yinhuang(阴黄)syndrome,jaundice with Yanghuang(阳黄)syndrome,hepatocellular jaundice,and hemolytic jaundice models.There are more western medicine models and fewer TCM syndrome models.In addition,there are a few drugs and therapies in western medicine for the treatment of jaundice and they have side effects.However,TCM shows ideal effect and the medicines are mild,with little irritation,which thus should be put on the top priority in the treatment of this disease.In the future,animal models of TCM syndromes should be improved,thereby laying a theoretical basis for the research and development of drugs and early prevention and treatment of the disease.

关 键 词：黄疸 中西医 动物模型 特点分析 

分 类 号：R575[医药卫生—消化系统] R-332[医药卫生—内科学]