GGA2在囊泡转运和相关疾病中作用的研究进展  

Recent findings with regard to roles of GGA2 in vesicle transport and related diseases

作　　者：陶逸豪 拜尔娜·木太力甫 祁正芳 刘昶吾 田园 韩洋洋 TAO Yihao;Baierna MUTAILIFU;QI Zhengfang;LIU Changwu;TIAN Yuan;HAN Yangyang(Department of Biology,School of Basic Medical Sciences,Xinjiang Medical University,Urumqi 830017,China;Xinjiang Key Laboratory of Molecular Biology for Endemic Diseases,Xinjiang Medical University,Urumqi 830017,China;Department of Human Anatomy&Histoembryology,College of Basic Medicine,Medicine School of Xi'an Jiaotong University,Xi'an 710061,China)

机构地区：[1]新疆医科大学基础医学院生物学教研室,新疆乌鲁木齐830017 [2]新疆地方病分子生物学重点实验室,新疆乌鲁木齐830017 [3]西安交通大学医学部基础医学院人体解剖与组织胚胎学系,陕西西安710061

出　　处：《中国病理生理杂志》2024年第3期543-550,共8页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.81902580);新疆维吾尔自治区高层次人才天池计划-全职创新人才基金;新疆医科大学大学生创新创业计划基金(No.CX2021059)

摘　　要：囊泡转运(vesicle transport)是大分子及颗粒性物质在细胞器间的跨膜转运方式,参与细胞多项重要的生命活动,如激素分泌、神经递质的释放及信息传递、天然免疫等,反式高尔基体网络(trans-Golgi network,TGN)-内体(endosome)运输作为其中一条途径,参与跨膜蛋白回收和重复利用[1]。TGN-内体运输缺陷引起的蛋白平衡紊乱和细胞功能紊乱,与恶性肿瘤、神经退行性疾病及糖尿病等多种疾病联系密切[2],如胶质瘤细胞中转接蛋白(adaptor pro-tein,AP)复合物1σ3的减少可抑制肿瘤增殖、侵袭和迁移[3];高尔基体相关、含γ-衔接蛋白耳(gamma-adaptin ear,GAE)的ADP核糖基化因子(ADP-ribo-sylation factor,ARF)结合蛋白3(Golgi-associated GAE-containing ARF-binding protein 3,GGA3)功能丧失引起β-分泌酶1(β-secretase 1)轴突积聚导致阿尔茨海默病早期病变[4]。Cellular dysfunction caused by vesicle transport is associated with a variety of diseases.The transGolgi network(TGN)to endosome transport is an important pathway of vesicle transport,and its defects leading to protein balance disorders has been linked to many diseases such as cancer,neurodegenerative diseases and diabetes mellitus.Gol gi-associated gamma-adaptin ear-containing ADP-ribosylation factor-binding protein 2(GGA2)is a crucial protein in volved in TGN-endosomal transport.It plays a significant role in the regulation of several diseases,including cancer,Al zheimer disease,type 2 diabetes mellitus and cerebral ischemia,by mediating protein transport with important biological significance.This article provides an overview of the molecular structure of GGA2,its role in regulating clathrin-mediated protein transport between TGN and endosomes,and its potential implications for a variety of diseases.

关 键 词：GGA2蛋白 囊泡转运 癌症 阿尔茨海默病 糖尿病 

分 类 号：R73[医药卫生—肿瘤] R742[医药卫生—临床医学] R587.1R329.2