神经胶质细胞钙信号对缺血性脑卒中所致神经功能损伤的影响  

Effect of neuroglial calcium signaling on neurological impairment in ischemic stroke

作　　者：陈钰洁 王磊 郑晨 CHEN Yujie;WANG Lei;ZHENG Chen(Department of Physiology,Zhuhai Campus of Zunyi Medical University,Zhuhai 519041,China)

机构地区：[1]遵义医科大学珠海校区生理学教研室,广东珠海519041

出　　处：《中国病理生理杂志》2024年第3期551-556,共6页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.81860230)。

摘　　要：脑卒中是一种由于脑部血液循环障碍导致局部神经功能缺失的疾病[1]。据《中国心血管健康与疾病报告2021》显示,该疾病仍是导致我国死亡人数最多的疾病,与2009年相比,死亡人数上升了12.4%[2]。其中,有87%为缺血性脑卒中患者[3]。Stroke is one of the leading causes of disability and death in China,but its mechanism has not been thoroughly elucidated.As an important class of cells in maintaining neurological homeostasis,the intracellular calcium signaling of glial cells plays a dual role in mitigating and exacerbating neuronal damage in stroke and largely determines the progression and outcome of stroke.In this review of the literature,focusing on astrocytes,which account for the largest proportion of glial cells,we review the mechanism of glial calcium signaling after stroke and its effect on post-stroke neuro logical function,to provide reference for post-stroke neuroprotection and repair.

关 键 词：神经胶质细胞 星形胶质细胞 钙信号 缺血性脑卒中 

分 类 号：R742[医药卫生—神经病学与精神病学] R338.2[医药卫生—临床医学] Q189[生物学—神经生物学]