内皮祖细胞与肿瘤的发生发展和治疗  

Endothelial progenitor cell and its role in tumorigenesis,development,and therap

作　　者：沈永雨 于戴浚 吴毅 童雨晨 杜来玲 Shen Yongyu;Yu Daijun;Wu Yi;Tong Yuchen;Du Lailing(Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province,Shulan International Medical College,Zhejiang Shuren University,Hangzhou 310015,China)

机构地区：[1]浙江树人学院树兰国际医学院,浙江省污染暴露与健康干预重点实验室,杭州310015

出　　处：《中国组织化学与细胞化学杂志》2023年第6期617-621,627,共6页Chinese Journal of Histochemistry and Cytochemistry

基　　金：国家自然科学基金资助项目(81700241)。

摘　　要：血管生成是各种生理和病理事件,特别是肿瘤发生和发展的重要过程。最近有证据表明,内皮祖细胞(endothelial progenitor cell, EPC)与肿瘤内皮细胞(tumor endothelial cell, TEC)的初始形成类似,在肿瘤血管的形成以及肿瘤的生长和扩散过程中起着重要作用。此外,大量研究表明,EPC及其相关的信号通路、生长因子等可以作为寻找更好的肿瘤治疗方法的突破口。本文综述目前对EPC的理解及其与肿瘤发展和进展的相互影响,特别是其在肿瘤血管生成中发挥的作用,并总结和讨论目前EPC与肿瘤治疗手段的相关性,以及二者结合对于肿瘤治疗手段进步的意义,强调进一步了解EPC及其与肿瘤间相互作用的重要性。Angiogenesis is a critical process in various physiological and pathological events,especially in the initiation and progression of tumors.Recent evidence suggests that endothelial progenitor cell(EPC)plays a significant role in the formation of tumor endothelial cell(TEC)and is crucial in the formation of tumor vasculature,as well as in tumor growth and metastasis.Additionally,extensive research indicates that EPCs and their associated signaling pathways and growth factors could be a breakthrough in finding better methods of tumor treatment.Therefore,this article reviews the current understanding of EPCs and their interaction with tumor development and progression,particularly their role in tumor angiogenesis.It also summarizes and discusses the relevance of EPCs to current cancer treatment approaches and the significance of combining these two in advancing cancer therapies,emphasizing the importance of further understanding EPCs and their interactions with tumors.

关 键 词：内皮祖细胞 肿瘤 血管新生 血管发生 治疗 

分 类 号：R364.3[医药卫生—病理学] R45[医药卫生—基础医学]