糖尿病视网膜病变患者血清TNF-α的水平及意义  

Significance of serum TNF-αlevels in patients with diabetic retinopathy

作　　者：汪丽玉 孙洪岩 王晶 赵慧攀 郑秀金 王君 刘丽连 杨明明 廖海兰 WANG Li-yu;SUN Hong-yan;WANG Jing;ZHAO Hui-pan;ZHENG Xiu-jin;WANG Jun;LIU Li-lian;YANG Ming-ming;LIAO Hai-lan(Guangdong Medical University,Zhanjiang 524023,China;Shenzhen People’s Hospital,Shenzhen 518000,China;Longgang District People’s Hospital,Shenzhen 518172,China)

机构地区：[1]广东医科大学,广东湛江524023 [2]深圳市人民医院,广东深圳518000 [3]深圳市龙岗区人民医院,广东深圳518172

出　　处：《广东医科大学学报》2024年第1期78-81,共4页Journal of Guangdong Medical University

基　　金：深圳市自然科学基金面上项目(JCYJ20210324113808023)。

摘　　要：目的分析糖尿病视网膜病变(DR)患者血清肿瘤坏死因子(TNF-α)水平及其意义。方法检测115例DR(DR组)、117例2型糖尿病(DM组)、121例单纯白内障(对照组)患者血清TNF-α和生化指标水平。结果DR组和DM组血清TNF-α水平高于对照组,其中DR组最高(P<0.01或0.05)。DR组血清TNF-α与肌酐、尿素氮、尿酸、收缩压呈正相关,而与肾小球滤过率、高密度脂蛋白胆固醇呈负相关(P<0.01或0.05)。ROC曲线分析显示,TNF-α曲线下面积为0.611。结论DR患者血清TNF-α升高与肾损伤指标密切相关。Objective To analyze the significance of serum TNF-αlevels in patients with diabetic retinopathy(DR).Methods Serum levels of TNF-αand biochemical indexes were determined in 115 DR,117 type 2 diabetes mellitus(DM),and 121 simple cataract(control group)patients.Results Serum TNF-αlevels were higher in DR and DM groups than in control group,especially in DR group(P<0.05).In DR group,serum TNF-αconcentrations were positively correlated with creatinine,blood urea nitrogen,uric acid,and systolic blood pressure,and negatively with eGFR and HDL-C(P<0.01 or 0.05).ROC curve analysis showed that the area under the curve of TNF-αwas 0.611.Conclusion Serum TNF-αlevels are associated with renal injury indicators in DR patients.

关 键 词：糖尿病视网膜病变 肿瘤坏死因子-Α 肾功能 

分 类 号：R774[医药卫生—眼科]