丁二磺酸腺苷蛋氨酸联合复方甘草酸苷治疗早期肝硬化的临床效果  

Clinical effect of ademetionine 1, 4-butanedisulfonate combined with compound glycyrrhizin in the treatment of early cirrhosis

作　　者：丘永芳 邱梅花[1] 邱小辉[1] QIU Yongfang;QIU Meihua;QIU Xiaohui(Department of Infection,the Second Hospital of Longyan,Fujian Province,Longyan 364000,China)

机构地区：[1]福建省龙岩市第二医院感染科,364000

出　　处：《临床合理用药杂志》2024年第9期20-22,27,共4页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的 观察丁二磺酸腺苷蛋氨酸联合复方甘草酸苷治疗早期肝硬化的临床效果。方法 选取2020年1月—2022年1月于龙岩市第二医院接受治疗的早期肝硬化患者75例,按随机数字表法分为甘草酸苷组(n=37)与联合用药组(n=38)。甘草酸苷组在常规治疗基础上给予复方甘草酸苷注射液,联合用药组在甘草酸苷组基础上给予注射用丁二磺酸腺苷蛋氨酸,2组均连续用药2周。比较2组临床疗效,用药前与用药2周后细胞黏附分子[可溶性细胞间黏附分子-1(sICAM-1)、血管细胞黏附分子-1(VCAM-1)]、肝纤维化指标[Ⅳ型胶原(Ⅳ-C)、Ⅲ型前胶原(PCⅢ)、透明质酸酶(HA)]、肝功能指标[γ-谷氨酰转移酶(GGT)、天冬氨酸氨基转移酶(AST)和丙氨酸氨基转移酶(ALT)],不良反应。结果 联合用药组总有效率高于甘草酸苷组(94.74%vs. 75.68%,χ^(2)=5.442,P=0.020)。用药2周后,2组血清sICMA-1、VCAM-1、ⅣC、PCⅢ、HA及GGT、AST、ALT水平低于用药前,且联合用药组低于甘草酸苷组(P<0.01)。甘草酸苷组不良反应总发生率与联合用药组比较,差异无统计学意义(13.51%vs. 21.05%,χ^(2)=0.744,P=0.389)。结论 丁二磺酸腺苷蛋氨酸联合复方甘草酸苷治疗早期肝硬化的效果较单用复方甘草酸苷更好,可更有效地改善机体黏附分子水平,减轻肝纤维化,提高肝功能,且具有较高的安全性。Objective To observe the clinical effect of ademetionine 1,4-butanedisulfonate combined with compound glycyrrhizin in the treatment of early cirrhosis.Methods Seventy-five patients with early cirrhosis who were treated in the Second Hospital of Longyan from January 2020 to January 2022 were selected and divided into the glycyrrhizin group(n=37)and the combination group(n=38)according to the random number table method.The glycyrrhizin group was given compound glycyrrhizin injection on the basis of conventional treatment,and the combination group was given ademetionine 1,4-butanedisulfonate for injection on the basis of glycyrrhizin group,and both groups were continuously given the drug for 2 weeks.The clinical efficacy,cell adhesion molecules(sICAM-1,VCAM-1),liver fibrosis indexes(Ⅳ-C,PCⅢ,HA),liver function indexes(GGT,AST,ALT)before and after 2 weeks of drug administration and adverse reactions were compared between the two groups.Results The total effective rate in the combination group was higher than the glycopyrrolate group(94.74%vs.75.68%,χ2=5.442,P=0.020).After 2 weeks of drug administration,serum sICMA-1,VCAM-1,Ⅳ-C,PCⅢ,HA and GGT,AST,ALT levels in the two groups were lower than those before drug administration,and those in the combination group were lower than the glycyrrhizin group(P<0.01).The total incidence of adverse reactions in the glycopyrrolate group was not statistically significant compared with that in the combination group(13.51%vs.21.05%,χ2=0.744,P=0.389).Conclusion Ademetionine 1,4-butanedisulfonate combined with compound glycyrrhizin is more effective than compound glycyrrhizin alone in the treatment of early cirrhosis,which can more effectively improve the level of adhesion molecules of the body,reduce hepatic fibrosis,and improve the hepatic function,and it has a high degree of safety.

关 键 词：肝硬化 早期 丁二磺酸腺苷蛋氨酸 复方甘草酸苷 肝功能 

分 类 号：R575.2[医药卫生—消化系统]