尼麦角林联合卡巴拉汀治疗对VD患者脑微循环及免疫功能的影响  

Influence of niergoline combined with rivastigmine in the therapy of VD patients on cerebral microcirculation and immune function

作　　者：吴婧 董兰真 张丽丽 张广玉 WU Jing;DONG Lan-zhen;ZHANG Li-li;ZHANG Guang-yu(Department of Neurology 7 District,Cangzhou People's Hospital,Cangzhou 061000,Hebei,China;Department of Neurology 1 District,Cangzhou People's Hospital,Cangzhou 061000,Hebei,China)

机构地区：[1]沧州市人民医院神经内科七区,河北沧州061000 [2]沧州市人民医院神经内科一区,河北沧州061000

出　　处：《川北医学院学报》2024年第3期324-327,共4页Journal of North Sichuan Medical College

基　　金：河北省医学科学研究课题计划项目(20210523)。

摘　　要：目的:探讨尼麦角林联合卡巴拉汀治疗对血管性痴呆(VD)患者脑微循环及免疫功能的影响。方法:选取92例VD患者为研究对象,根据治疗方式不同分为对照组和研究组,每组各46例。对照组患者给予基础治疗+卡巴拉汀治疗;研究组在对照组基础上加尼麦角林治疗,两组患者疗程均为3个月。比较两组患者临床疗效、治疗前后认知功能[简易精神状态量表(MMSE)评分]及生活质量[Barthel指数(BI)评分]、脑微循环[最大血流速度(Vmax)、最小血流速度(Vmin)、外周阻力(Rv)、动态阻力(Dr)]及免疫功能[免疫球蛋白IgA、IgM及IgG水平]。结果:研究组患者临床总有效率高于对照组(93.48%vs.80.43%,P<0.05)。治疗后,两组患者MMSE及BI评分、Vmax及Vmin、IgA、IgM及IgG水平均升高(P<0.05),且研究组高于对照组(P<0.05);Rv、Dr水平均降低(P<0.05),且研究组低于对照组(P<0.05)。结论:尼麦角林联合卡巴拉汀治疗VD患者临床疗效好,能有效改善患者认知功能、生活质量、脑微循环及免疫功能。Objective:To explore the influence of niergoline combined with rivastigmine in the therapy of patients with vascular dementia(VD)on cerebral microcirculation and immune function.Methods:A total of 92 VD patients were choosed and split into control group and research group according to different treatment methods,with 46 cases in each group.Control group were treated with basic therapy+capalatine,and the research group were treated with control group+niergoline,and both groups of patients had a course of 3 months.The curative effect after therapy,cognitive function[mini-mental state scale(MMSE)score],quality of life[Barthel index(BI)score],cerebral microcirculation[maximum blood flow velocity(Vmax),minimum blood flow velocity(Vmin),peripheral resistance(Rv),dynamic resistance(Dr)],and immune function[immunoglobulin IgA,IgM,and IgG levels]were compared between the two groups before and after treatment.Results:After therapy,the overall clinical effective rate after therapy of research group was 93.48%,which was higher in comparison with 80.43%of the control group(P<0.05).The MMSE,BI scores,Vmax,Vmin,IgA,IgM and IgG levels after therapy of the two groups were increased in comparison with before therapy(P<0.05),and the research group were higher than the control group(P<0.05).The Rv and Dr after therapy of the two groups were decreased in comparison with before therapy(P<0.05),and the research group were lower than the control group(P<0.05).Conclusion:The curative effect of niergoline combined with rivastigmine in the therapy of VD patients is remarkable,and it can improve the cognitive function,living quality,cerebral microcirculation and immune function.

关 键 词：血管性痴呆 尼麦角林 卡巴拉汀 脑微循环 免疫功能 

分 类 号：R749.13[医药卫生—神经病学与精神病学]