桂枝茯苓胶囊联合戈舍瑞林对子宫肌瘤患者内分泌功能的影响  

Effect of Guizhi Fuling capsule combined with Goserelin on endocrine function in patients with uterine fibroids

作　　者：周灵雪 张瑞玉 赵娜 ZHOU Ling-xue;ZHANG Rui-yu;ZHAO Na(Department of Gynecology,Zhangjiakou First Hospital,Zhangjiakou 075000,Hebei,China)

机构地区：[1]张家口市第一医院妇科,河北张家口075000

出　　处：《川北医学院学报》2024年第3期397-400,共4页Journal of North Sichuan Medical College

摘　　要：目的:探讨桂枝茯苓胶囊联合戈舍瑞林治疗UFE的疗效。方法:将83例UFE患者按照治疗方式不同分为A组(n=41)和B组(n=42)。A组给予注射用戈舍瑞林微球;B组在A组基础上给予桂枝茯苓胶囊。两组均持续治疗3个月。比较两组临床疗效、血液流变学指标、内分泌功能、病灶形态、血清人附睾蛋白4(HE4)、癌抗原125(CA125)、血管紧张素Ⅱ(AngⅡ)、干扰素γ(IFN-γ)水平及生活质量。结果:治疗后,B组总有效率为95.24%,高于A组的78.05%(P<0.05)。治疗后,两组血液流变学、内分泌功能指标、血清HE4、CA125、AngⅡ、IFN-γ水平均降低,且B组低于A组(P<0.05);子宫体积和UFE体积均缩小,且B组小于A组(P<0.05);生活质量各项评分均升高,且B组高于A组(P<0.05)。结论:UFE患者经桂枝茯苓胶囊与戈舍瑞林联合治疗可改善血液流变学高凝状态及内分泌功能,调节相关因子水平,提高治疗效果及患者生活质量。Objective:To explore the therapeutic effect of Guizhi Fuling Capsule combined with Gosserine in the treatment of uterine fibroids(UFE).Methods:83 patients with UFE were divided into the group A(n=41)and the group B(n=42)according to different treatment methods.The group A was given injectable Goserelin microspheres,while the group B was given Guizhi Fuling capsules on the basis of the group A.Both groups continued treatment for 3 months.The clinical efficacy,including blood rheology indicators,endocrine function,lesion morphology,human epididymis protein 4(HE4),cancer antigen 125(CA125),angiotensin II(Ang II),interferon-γ(IFN-γ),and quality of life between two groups were compared.Results:After 3 months of treatment,the total effective rate of the group B was 95.24%,which was higher than the group A's 78.05%(P<0.05).Hemorheology,endocrine function indexes,levels of serum HE4,CA125,AngⅡ,IFN-γin two groups decreased with the treatment time,and the levels in the group B were lower than those in the group A(P<0.05).Uterine volume and UFE volume decreased with treatment time,and the group B was smaller compared with the group A(P<0.05).The scores of quality of life increased with the treatment time,and compared with the group A,the group B was higher(P<0.05).Conclusion:The combination treatment of Guizhi Fuling capsules and Goserellin could improve hemorheological hypercoagulability and endocrine function in patients with UFE,regulate the levels of related factors,improve treatment efficacy,and enhance the quality of life of patients.

关 键 词：子宫肌瘤 戈舍瑞林 桂枝茯苓胶囊 内分泌功能 病灶形态 

分 类 号：R7373.33[医药卫生—肿瘤]