外周血髓源性抑制细胞表达及其与初诊食管癌患者病理特征和预后的相关性  

Correlation of myeloid-derived suppressor cells in peripheral blood with pathological features and prognosis of newly diagnosed esophageal cancer patients

作　　者：何翠 汪虹[1] 江玉荣 HE Cui;WANG Hong;JIANG Yurong(Department of Pathology,Huanggang Hospital of Traditional Chinese Medicine,Huanggang,Hubei,438000,China;Department of Laboratory Medicine,Huanggang Hospital of Traditional Chinese Medicine,Huanggang,Hubei,438000,China)

机构地区：[1]黄冈市中医医院病理科,湖北黄冈438000 [2]黄冈市中医医院检验科,湖北黄冈438000

出　　处：《当代医学》2023年第36期110-113,共4页Contemporary Medicine

摘　　要：目的探讨外周血髓源性抑制细胞(MDSCs)表达及其与初诊食管癌患者病理特征和预后的相关性。方法回顾性分析2017年1月至2020年12月黄冈市中医医院收治的150例初诊食管癌患者(观察组)的临床资料,其中61例患者于本院接受食管癌根治术,统计术后随访患者复发情况。另收集同期87名健康志愿者(对照组)的临床资料。比较两组MDSCs表达水平,单因素及多因素Logistic回归分析食管癌患者术后复发转移的影响因素。结果观察组外周血MDSCs表达水平高于对照组,差异有统计学意义(P<0.05)。初诊食管癌患者TNMⅢ/Ⅳ期、中低分化型、淋巴结转移者外周血MDSCs表达水平均高于Ⅰ/Ⅱ期、高分化型、淋巴结未转移者,差异有统计学意义(P<0.05)。61例接受食管癌根治术患者中,复发转移17例,未复发转移44例。复发转移患者肿瘤直径>5cm、TNM分期为Ⅲ/Ⅳ期、分化程度为中低分化型、淋巴结转移比例及外周血MDSCs表达水平均高于未复发转移患者(P<0.05);两者年龄、癌肿位置比较差异无统计学意义。多因素Logistic回归分析显示,TNM分期、淋巴结转移、MDSCs表达是初诊食管癌患者术后复发转移的独立危险因素(P<0.05)。结论初诊食管癌患者外周血MDSCs呈高表达,食管癌TNM分期、分化类型、淋巴结是否转移与外周血MDSCs水平表达相关,并在术后复发转移监测中有一定指导意义。Objective To investigate the correlation of myeloid-derived suppressor cells(MDSCs)in peripheral blood with pathological features and prognosis of newly diagnosed esophageal cancer patients.Methods The clinical data of 150 patients with newly diagnosed esophageal cancer(observation group)admitted to Huanggang Hospital of Traditional Chinese Medicine from January 2017 to December 2020 were retrospectively ana-lyzed.Among them,61 patients underwent radical resection of esophageal cancer in our hospital,and the recurrence of postoperative follow-up pa-tients was counted.The clinical data of 87 healthy volunteers(control group)in the same period were collected.The expression levels of MDSCs were compared between the two groups,univariate and multivariate Logistic regression analysis were used to analyze the influencing factors of post-operative recurrence and metastasis in patients with esophageal cancer.Results The expression level of MDSCs in peripheral blood in the observa-tion group was higher than that in the control group,and the difference was statistically significant(P<0.05).The expression levels of MDSCs in pe-ripheral blood of patients with newly diagnosed esophageal cancer in TNM stageⅢ/Ⅳ,moderately and poorly differentiated,and lymph node metas-tasis were higher than those in stageⅠ/Ⅱ,highly differentiated,and non-lymph node metastasis,and the differences were statistically significant(P<0.05).Among 61 patients who underwent radical resection for esophageal cancer,17 had recurrence and metastasis and 44 had no recurrence and me-tastasis.The proportion of patients with tumor diameter>5 cm,TNM stageⅢ/Ⅳ,moderate and low differentiation,lymph node metastasis and pe-ripheral blood MDSCs expression in patients with recurrence and metastasis were higher than those in patients without recurrence and metastasis(P<0.05).There were no significant differences in age and tumor location between the two groups.Multivariate Logistic regression analysis showed that TNM stage,lymph node metastasis and MDSCs ex

关 键 词：食管癌 髓源性抑制细胞 病理特征 预后 相关性 

分 类 号：R735.1[医药卫生—肿瘤]