Lung microbiome:new insights into the pathogenesis of respiratory diseases  

作　　者：Ruomeng Li Jing Li Xikun Zhou 

机构地区：[1]Department of Biotherapy,Cancer Center and State Key Laboratory of Biotherapy,West China Hospital,Sichuan University,Chengdu 610041,China [2]State Key Laboratory of Oral Diseases,National Clinical Research Center for Oral Diseases,Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management,West China Hospital of Stomatology,Sichuan University,Chengdu,Sichuan 610041,China

出　　处：《Signal Transduction and Targeted Therapy》2024年第2期652-678,共27页信号转导与靶向治疗（英文）

基　　金：supported by the National Natural Science Foundation of China(No.82241049,81922042,82072999,82172285 and 82273320);the 1·3·5 Project of Excellent Development of Discipline of West China Hospital of Sichuan University(No.ZYYC21001);the“Zero to One”Innovation Research Project of Sichuan University(No.2022SCUH0029).

摘　　要：The lungs were long thought to be sterile until technical advances uncovered the presence of the lung microbial community.The microbiome of healthy lungs is mainly derived from the upper respiratory tract(URT)microbiome but also has its own characteristic flora.The selection mechanisms in the lung,including clearance by coughing,pulmonary macrophages,the oscillation of respiratory cilia,and bacterial inhibition by alveolar surfactant,keep the microbiome transient and mobile,which is different from the microbiome in other organs.The pulmonary bacteriome has been intensively studied recently,but relatively little research has focused on the mycobiome and virome.This up-to-date review retrospectively summarizes the lung microbiome’s history,composition,and function.We focus on the interaction of the lung microbiome with the oropharynx and gut microbiome and emphasize the role it plays in the innate and adaptive immune responses.More importantly,we focus on multiple respiratory diseases,including asthma,chronic obstructive pulmonary disease(COPD),fibrosis,bronchiectasis,and pneumonia.The impact of the lung microbiome on coronavirus disease 2019(COVID-19)and lung cancer has also been comprehensively studied.Furthermore,by summarizing the therapeutic potential of the lung microbiome in lung diseases and examining the shortcomings of the field,we propose an outlook of the direction of lung microbiome research.

关 键 词：RESPIRATORY DISEASES LUNG 

分 类 号：R563[医药卫生—呼吸系统]