血清IL-11水平在急性脑梗死患者诊断和预后中的评估价值及其与血清脑源性神经营养因子的相关性  

Evaluation value of serum interleukin⁃11 level in diagnosis and prognosis of patients with acute cerebral infarction and its correlation with serum brain⁃derived neurotrophic factor

作　　者：赵晶[1] 钱进军[1] ZHAO Jing;QIAN Jinjun(Department of Neurology,Affiliated Fourth People’s Hospital of Jiangsu University,Zhenjiang 212001,China)

机构地区：[1]江苏大学附属第四人民医院神经内科,镇江212001

出　　处：《临床神经病学杂志》2024年第1期32-36,共5页Journal of Clinical Neurology

基　　金：镇江市科技创新资金(重点研发计划——社会发展)(SH2023070)。

摘　　要：目的探讨血清IL-11在急性脑梗死诊断和预后评估中的价值及其与血清脑源性神经营养因子(BDNF)的相关性。方法收集102例急性脑梗死患者(脑梗死组)和64名正常对照者(正常对照组)的一般临床资料。根据90 d mRS评分将脑梗死组分为预后良好亚组和预后不良亚组。采用Pearson相关性分析血清IL-11和NIHSS评分、脑梗死体积、血清BDNF的相关性,Logistics回归分析脑梗死预后的影响因素,并绘制IL-11在脑梗死诊断和预后预测中的ROC曲线。结果脑梗死组高血压比率及糖化血红蛋白、低密度脂蛋白水平显著高于正常对照组(均P<0.05)。预后不良亚组的年龄、糖尿病比率、糖化血红蛋白水平、入院时NIHSS评分、脑梗死体积显著高于预后良好亚组(均P<0.05)。脑梗死组血清IL-11水平显著低于正常对照组(t=10.123,P<0.001)。脑梗死预后不良亚组血清IL-11水平显著低于预后良好亚组(t=7.438,P<0.001)。脑梗死患者血清IL-11表达与NIHSS评分(r=-0.603,P<0.001)及脑梗死体积(r=-0.681,P<0.001)呈负相关关系。Logistics回归分析显示,IL-11为影响脑梗死患者预后的保护性因素(OR=0.814,P=0.009),脑梗死体积(OR=2.262,P<0.001)和NIHSS评分(OR=2.107,P=0.006)为影响脑梗死预后的危险因素。当IL-11应用于脑梗死的诊断时,ROC曲线下面积为0.841,灵敏性为91.18%,特异性为72.42%,截断值为378.47;当IL-11应用于脑梗死预后预测时,ROC曲线下面积为0.786,灵敏性为67.09%,特异性为87.93%,截断值为310.94。脑梗死患者血清IL-11水平与血清BDNF水平的相关系数为r=0.711、P<0.01。结论脑梗死患者血清IL-11水平显著降低,且预后不良患者的IL-11水平显著低于预后良好亚组。同时,IL-11水平与血清BDNF水平呈负相关,可能可以用于脑梗死的辅助诊断和预后评估。Objective To explore the value of serum IL⁃11 in the diagnosis and prognosis evaluation of acute cerebral infarction and its correlation with serum brain⁃derived neurotrophic factor(BDNF).Methods General clinical data of 102 patients with acute cerebral infarction(cerebral infarction group)and 64 normal controls(normal control group)were collected.According to the 90 d mRS score,the cerebral infarction group was divided into the good prognosis subgroup and the poor prognosis subgroup.Pearson correlation analysis was used to analyze the correlation between serum IL⁃11 and NIHSS score,cerebral infarction volume and serum BDNF.Logistics regression analysis was used to analyze the influencing factors of cerebral infarction prognosis,and the ROC curve of IL⁃11 in the diagnosis and prognosis of cerebral infarction was drawn.Results The rate of hypertension and the levels of glycosylated hemoglobin and low⁃density lipoprotein in the cerebral infarction group were significantly higher than those in the normal control group(all P<0.05).The age,rate of diabetes,glycosylated hemoglobin level,NIHSS score at admission and cerebral infarction volume in the poor prognosis subgroup were significantly higher than those in the good prognosis subgroup(all P<0.05).The level of serum IL⁃11 in the cerebral infarction group was significantly lower than that in the normal control group(t=10.123,P<0.05).The serum IL⁃11 level in the poor prognosis subgroup of the cerebral infarction group was significantly lower than that in the good prognosis subgroup(t=7.438,P<0.05).The expression of serum IL⁃11 in patients with cerebral infarction was negatively correlated with NIHSS score(r=-0.603,P<0.001)and cerebral infarction volume(r=-0.681,P<0.001).Logistics regression analysis showed that IL⁃11 was a protective factor(OR=0.814,P=0.009),while infarct volume(OR=2.262,P<0.001)and NIHSS score(OR=2.107,P=0.006)were risk factors affecting the prognosis of patients with cerebral infarction.When IL⁃11 was applied to the diagnosis of

关 键 词：脑梗死 IL-11 诊断 预后 脑源性神经营养因子 

分 类 号：R743.3[医药卫生—神经病学与精神病学]