老年高血压合并抑郁与其激素水平的关系  

Relationship between hypertension combined with depression and hormone levels in the elderly patients with hypertension

作　　者：王燕敏 蔡敏[2] WANG Yanmin;CAI Min(Zhengzhou Traditional Chinese Medicine Hospital,Zhengzhou 450007,China)

机构地区：[1]郑州市中医院,郑州450007 [2]中国人民解放军联勤保障部队第988医院

出　　处：《国际精神病学杂志》2024年第1期195-198,共4页Journal Of International Psychiatry

摘　　要：目的 探讨合并抑郁的老年高血压患者与其激素水平的关系。方法 本研究观察对象为2021年8月~2022年12月92例老年高血压患者,进行抑郁筛查,并根据筛查结果设为抑郁组与对照组,比较两组患者一般资料、甲状腺激素、血管紧张素及醛固酮水平,分析抑郁组汉密尔顿抑郁量表-17(Hamilton depression rating scale-17,HAMD-17)与激素水平的相关性。结果 92例老年高血压患者合并抑郁26例;抑郁组与对照组年龄、病程、血压控制效果、独居、合并相关并发症等资料差异具有统计学意义(P<0.05),两组性别、居住地、受教育年限差异无统计学意义(P>0.05);抑郁组促甲状腺激素(thyroid-stimulating hormone,TSH)、血管紧张素Ⅰ(angiotensinⅠ,Ang Ⅰ)、血管紧张素Ⅱ(angiotensin Ⅱ,Ang Ⅱ)、醛固酮水平显著高于对照组,三碘甲状腺原氨酸(triiodothyronine,T3)、甲状腺素(tetraiodothyronine,T4)水平显著低于对照组(P<0.05);抑郁组HAMD-17评分与TSH、Ang Ⅰ、Ang Ⅱ水平呈正相关,与T3、T4水平呈负相关(P<0.05),与醛固酮水平无显著相关性(P>0.05)。结论 老年高血压病抑郁发生率较高,且合并抑郁与甲状腺激素水平低下,Ang Ⅰ、Ang Ⅱ水平升高具有明显关联。Objective To explore the relationship between depression and hormone levels in elderly patients with hypertension.Methods Ninety-two elderly hypertensive patients who underwent depression screening from August 2021 to December 2022 were selected as the study subjects,and depression screening were conducted.They were set as the depression group and the control group based on screening results.The general information,Thyroid hormones level,angiotensin and aldosterone levels of the two groups were compared.The correlation between Hamilton depression rating scale(HAMD-17)and Thyroid hormones level in depression group were analyzed.Results 92 elderly hypertensive patients with depression in 26 cases.There was a statistically significant difference between the depression group and the control group in terms of disease course,blood pressure control effect,living alone,and complications related to hypertension(P<0.05).There was no statistically significant difference in gender,place of residence,and years of education between the two groups(P>0.05).The level of Thyroid-stimulating hormone(TSH),angiotensinⅠ(AngⅠ),angiotensinⅡ(AngⅡ),and aldosterone in the depression group was significantly higher than that in the control group,and the levels of Triiodothyronine(T3)and Thyroxine(T4)were significantly lower than that in the control group(P<0.05).The HAMD-17 score in the depression group was positively correlated with TSH,Ang,and AngⅡlevels,and negatively correlated with T3、T4 levels(P<0.05).There was no significant correlation with aldosterone level(P>0.05).Conclusion The incidence of depression in elderly patients with hypertension is higher,and depression is associated with low thyroid hormone levels,AngⅠand AngⅡlevels.

关 键 词：老年 高血压 抑郁 甲状腺激素 血管紧张素 醛固酮 

分 类 号：R749[医药卫生—神经病学与精神病学]