血浆离子钙及血清总钙在恶性肿瘤患者中的临床价值  

Clinical value of plasma ionized calcium and total serum calcium in patients with malignant tumors

作　　者：种烁阳 孙长江[2] Zhong Shuoyang;Sun Changjiang(Nantong Center for Disease Control and Prevention,Nantong,Jiangsu 226001,China;Affiliated Hospital of Nantong University,Nantong,Jiangsu 226001,China)

机构地区：[1]南通市疾病预防控制中心,江苏南通226001 [2]南通大学附属医院,江苏南通226001

出　　处：《齐齐哈尔医学院学报》2024年第2期154-157,共4页Journal of Qiqihar Medical University

摘　　要：目的探究晚期恶性肿瘤患者检测血浆离子钙(ICa)和血清总钙(TCa)的临床意义。方法选择2020年5月—2023年7月XX大学附属医收治的122例肿瘤患者为研究对象,将其设置为观察组;再选取同期100名健康体检人群作为对照组。对两组研究对象均开展生化检验,收集清蛋白(Alb)、总钙(TCa)、离子(ICa)、pH的临床生化实验室检测结果,并根据公式计算观察组和对照组的校正离子钙水平(nICa)和校正总钙水平(cTCa),将数据整理进行统计学分析比较。结果观察组中cTCa水平[(2.53±0.28)mmol/L]和nICa水平[(1.29±0.17)mmol/L]均高于对照组(P<0.05);观察组中Alb水平[(40.72±5.79)mmol/L]和ICa水平[(1.02±0.08)mmol/L]均低于对照组(P<0.05),两组中TCa水平[(2.15±0.17)mmol/L]和pH[(7.32±0.55)mmol/L]差异无统计学意义(P>0.05)。观察组血钙异常的患者nICa的阳性率高于cTCa,差异有统计学意义(P<0.05)。结论测定血浆nICa水平比血清总钙TCa有价值,能够对肿瘤伴血钙异常患者进行早期诊断,也能够对治疗后的患者提供预后监测,以便于制定科学合理的治疗方案,提高肿瘤患者的生活质量。Objective To investigate the clinical significance of detecting plasma ionized calcium(ICa)and serum total calcium(TCa)in patients with advanced malignant tumors.Methods 122 cases of tumor patients receiving treatment in the Inpatient Department of the Affiliated Hospital of Nantong University from May 2020 to July 2023 were selected as the study subjects,they were set as the observation group,and then 100 cases of healthy people receiving physical examination during the same period were selected as the control group.Biochemical tests were carried out on both the observation group and the control group,and the clinical biochemical laboratory test results of albumin(Alb),total calcium(TCa),ion(ICa),and pH were collected,and the corrected ionic calcium level(nICa),the corrected total calcium level(cTCa)of the observation group and the control group were calculated according to the formula,and the data were organized to be statistically analyzed and compared.Results The cTCa level(2.53±0.28)and nICa level(1.29±0.17)in the observation group were significantly higher than those in the control group(P<0.05);the Alb(40.72±5.79)and ICa levels(1.02±0.08)in the observation group were lower than those in the control group,with statistically significant differences(P<0.05);the differences in TCa level(2.15±0.17)and pH(7.32±0.55)were not statistically significant between the two groups(P>0.05).nICa(1.29±±0.17)and pH(7.32±0.55)were not statistically significant(P>0.05).The positive rate of nICa was higher than that of cTCa in patients with abnormal blood calcium in the observation group,and the difference was statistically significant(P<0.05).Conclusions Determination of plasma nICa level is valuable than serum total calcium for early diagnosis of patients with tumors accompanied by calcium abnormalities,as well as for providing prognostic monitoring of treated patients,so as to facilitate the development of a scientific and rational therapeutic plan and improve the quality of life of tumor patients.

关 键 词：离子钙 总钙 肿瘤 预后监测 

分 类 号：R730.4[医药卫生—肿瘤]