NPM1表达与子宫内膜癌患者临床病理特征参数的相关性分析  

Correlation analysis between NPM1 expression and clinical pathological characteristic parameters in patients with endometrial cancer

作　　者：郑莹莹 田晓予[1] 霍礼娜 ZHENG Yingying;TIAN Xiaoyu;HUO Lina(Clinical Medicine School of Henan University of Science and Technology,Obstetrics and Gynecology Department of the First Affiliated Hospital of Henan University of Science and Technology,Luoyang,Henan 471000,China)

机构地区：[1]河南科技大学临床医学院/河南科技大学第一附属医院妇产科,河南洛阳471000

出　　处：《中国优生与遗传杂志》2024年第2期311-314,共4页Chinese Journal of Birth Health & Heredity

摘　　要：目的 探讨核磷蛋白1(NPM1)表达与子宫内膜癌(EC)患者临床病理特征参数及预后的相关性。方法 收集2019年1月至2020年7月间在河南科技大学第一附属医院就诊的100例EC患者的癌组织及其癌旁组织,根据患者3年预后情况,分为生存组(79例)和死亡组(21例)。免疫组织化学法检测组织中NPM1的水平,并探讨NPM1表达与EC临床特征的关系。采用Kaplan-Meier法对NPM1表达与EC患者3年生存率间的关系进行分析。使用Cox回归法研究影响EC患者死亡的独立危险因素。结果 EC组织NPM1阳性表达率高于癌旁组织(P<0.05)。TNM分期Ⅲ~Ⅳ期、有淋巴结转移、肌层浸润深度≥1/2的EC患者NPM1阳性表达率显著高于无淋巴结转移、TNM分期Ⅰ~Ⅱ期、肌层浸润深度<1/2的患者(P<0.05)。NPM1阳性表达患者3年累积生存率明显低于阴性表达患者生存率(P<0.05)。死亡组NPM1呈现阳性表达、TNM分期Ⅲ~Ⅳ期、有淋巴结转移及肌层浸润深度≥1/2的EC患者的比例显著高于生存组(P<0.05)。影响EC患者死亡的独立危险因素为NPM1(P<0.05)。结论 NPM1阳性表达与EC患者临床病理参数及预后有关,可能成为预测EC预后的标志物。Objective To explore the correlation between the expression of nucleophosmin 1(NPM1) and the clinical pathological parameters and prognosis of endometrial cancer(EC) patients.Methods 100 EC patients' cancer tissues and their paracancerous tissues were collected from the First Affiliated Hospital of Henan University of Science and Technology(HUST)from January 2019 to July 2020,and according to the three-year prognosis of the patients,they were divided into the survival group(79 cases) and the death group(21 cases).The level of NPM1 in tissues was detected by immunohistochemistry and the relationship between NPM1 expression and clinical features of EC was investigated.Kaplan-Meier method was applied to analyze the relationship between NPM1 expression and 3-year survival rate in EC patients.Cox proportional risk regression analysis method was applied to analyze independent risk factors affecting mortality in EC patients.Results NPM1 positive expression rate in EC tissues was higher than that in paracancerous tissues(P<0.05).The positive expression rate of NPM1 in EC tissues of patients with TNM stage Ⅲ–Ⅳ,lymph node metastasis,and myometrial invasion depth≥1/2 was obviously higher than that of patients with TNM stage Ⅰ–Ⅱ,non lymph node metastasis,and myometrial invasion depth<1/2(P<0.05).The 3-year cumulative survival rate of patients with positive NPM1 expression was significantly lower than that of patients with negative expression(P<0.05).The proportions of EC patients with positive expression of NPM1,TNM stage Ⅲ–Ⅳ,lymph node metastasis,and myometrial invasion depth ≥1/2 in the death group were obviously higher than those in the survival group(P<0.05).The independent risk factor for mortality in EC patients was NPM1(P<0.05).Conclusion The positive expression of NPM1 was related to the clinical pathological parameters and prognosis of EC patients,and may become a biomarker for predicting the prognosis of EC.

关 键 词：子宫内膜癌 核磷蛋白1 临床病理参数 预后 

分 类 号：R737.33[医药卫生—肿瘤]