革兰氏阴性菌细胞表面多糖的应用潜力  

Application Potential of Cell-Surface Polysaccharide of Gram-Negative Bacteria

作　　者：刘菲 黄柯 郑积敏[1] LIU Fei;HUANG Ke;ZHENG Ji-Min(College of Chemistry,Beijing Normal University,Beijing 100875,China)

机构地区：[1]北京师范大学化学学院,北京100875

出　　处：《化学教育（中英文）》2024年第6期1-10,共10页Chinese Journal of Chemical Education

摘　　要：细菌自身能够合成各种多糖分子,并分泌于细菌表面形成多糖保护层。当细菌处于恶劣环境时,多糖保护层能够调节细菌适应周围环境,从而使其存活。革兰氏阴性细菌分泌的主要多糖成分包括脂多糖、荚膜多糖、胞外多糖,它们通常是引起人体中产生强烈免疫反应的有效抗原,对细菌的致病性至关重要。因此研究它们的结构和合成转运机制等具有十分重要的作用,可以为细菌多糖运输途径的靶点药物设计等提供创新性的指导与思路。本文对细菌多糖的结构、合成转运机制、影响和作用等方面进行重点介绍。Bacteria can synthesize a variety of polysaccharide molecules and secrete on the surface of bacteria to form a polysaccharide protective layer.When the bacteria are in a harsh environment,the polysaccharide protective layer can adjust the bacteria to adapt to the surrounding environment,so as to make them survive.The main polysaccharides secreted by Gram-negative bacteria include lipopolysaccharides,capsular polysaccharides and extracellular polysaccharides,which are usually effective antigens that cause strong immune response in human body and are very important for the pathogenicity of bacteria.Therefore,it is very important to study their structure and synthetic transport mechanism,which can provide innovative guidance and ideas for the target drug design of bacterial polysaccharide transport routes.This paper will focus on the structure,synthetic transport mechanism,function and influence and other aspects of bacterial polysaccharides.

关 键 词：脂多糖 荚膜多糖 胞外多糖 结构 合成转运机制 影响和作用 

分 类 号：Q939.9[生物学—微生物学]