小檗碱药物的研究进展  

Research Progress of Berberine Drugs

作　　者：张海霞 梅梅[2] Zhang Haixia;Mei Mei(Jiamusi University,Jiamusi 154000;The First Affiliated Hospital of Jiamusi University,Jiamusi 154000,China)

机构地区：[1]佳木斯大学,黑龙江佳木斯154000 [2]佳木斯大学附属第一医院,黑龙江佳木斯154000

出　　处：《广东化工》2024年第1期75-77,85,共4页Guangdong Chemical Industry

基　　金：黑龙江省省属高等学校基本科研业务费科研项目(2020-KYYWF-0284);国家重点专科建设项目团队:儿科科研团队(GJ202301)。

摘　　要：代谢性疾病发病率的增加严重影响了全世界的人类健康和生命安全。从天然化合物中寻找治疗代谢性疾病的有效药物具有重要意义。小檗碱一种重要的季铵类生物碱,多存在于许多传统药用植物中,近年来,动物和临床研究都证明,小檗碱及其代谢产物对代谢性疾病具有良好的治疗效果。本文综述了小檗碱合成及提取工艺,及其在糖尿病、高尿酸血症等代谢性疾病中的药理活性,为进一步开发和利用小檗碱提供更加坚实的理论依据。The increase in the incidence of metabolic diseases seriously affects human health and life safety worldwide.It is important to find effective drugs for the treatment of metabolic diseases from natural compounds.Berberine is an important quaternary ammonium alkaloid,mostly found in many traditional medicinal plants,in recent years,animal and clinical studies have proved that berberine and its metabolites have a good therapeutic effect on metabolic diseases.This article reviews the synthesis and extraction process of berberine and its pharmacological activities in metabolic diseases such as diabetes and hyperuricemia,so as to provide a more solid theoretical basis for the further development and utilization of berberine.

关 键 词：小檗碱 合成及提取 抗菌作用 抗肿瘤作用 降血糖作用 

分 类 号：TQ[化学工程]