多模式镇痛对原发性肝癌患者休斯顿疼痛情况调查表评分及血清结合珠蛋白水平的影响  

InfLuences of multimodal analgesia on HPOI score and serum haptoglobin level in patients with hepatocellular carcinoma

作　　者：李晓勤 王群 何晓兰 吕岩 王锦龙 LI Xiaoqin;WANG Qun;HE Xiaolan;LYU Yan;WANG Jinlong(Department of Anesthesia and Perioperative Medicine,the First Affiliated Hospital of Air Force Medical University,Xi’an 710032,China)

机构地区：[1]空军军医大学第一附属医院麻醉与围术期医学科,陕西西安710032

出　　处：《陕西医学杂志》2024年第4期475-478,共4页Shaanxi Medical Journal

基　　金：国家自然科学基金资助面上项目(81971058)。

摘　　要：目的:探究多模式镇痛(MA)对原发性肝癌(HCC)患者休斯顿疼痛情况调查表(HPOI)评分及血清结合珠蛋白水平的影响。方法:选择原发性肝癌患者78例作为研究对象,按照随机数字表法分组,分为对照组(n=39,给予传统镇痛方式)与观察组(n=39,在对照组的基础上采取多模式镇痛方式)。比较两组患者的HPOI评分、不良反应情况,并测定两组患者血清结合珠蛋白水平。结果:干预后,观察组镇痛药使用少于对照组(P<0.05)。观察组HPOI评分优于对照组(P<0.05)。观察组术后8、12、24 h VAS评分均低于对照组(均P<0.05)。干预后,两组患者血清结合珠蛋白水平均有所降低(P<0.05),且观察组血清结合珠蛋白水平低于对照组(P<0.05)。观察组恶心呕吐、胃肠道不适、呼吸抑制、头晕头痛等不良反应率较对照组低(均P<0.05)。结论:多模式镇痛能够有效提升原发性肝癌患者镇痛满意度,减少术后镇痛药物使用,缓解病情。Objective:To explore the influences of multimodal analgesia(MA)on the Houston Pain Outcome Instrument(HPOI)score and serum haptoglobin level in patients with hepatocellular carcinoma(HCG).Methods:Seventy-eight patients with primary liver cancer were regarded as the research subjects,and grouped into control group(39 cases,given traditional analgesia)and observation group(39 cases,given multimodal analgesia on the basis of control group)according to random number table method.The total HPOI score,and adverse reactions were compared between the two groups,and the serum haptoglobin levels were determined in the two groups.Results:After the intervention,the use of analgesics in the observation group was less than that in the control group(P<0.05).The HPOI score of the observation group was better than that of the control group(P<0.05).The VAS scores of the observation group at 8,12 and 24 hours after operation were lower than those of the control group(all P<0.05).After the intervention,the serum haptoglobin levels of the two groups were decreased,and the serum haptoglobin level in the observation group was lower than that in the control group(all P<0.05).The ADR rate of nausea,vomiting,gastrointestinal discomfort,respiratory depression,dizziness and headache in the observation group was lower than that in the control group(P<0.05).Conclusion:Multimodal analgesia can effectively improve the analgesic satisfaction of patients with primary liver cancer,reduce postoperative analgesics use,and relieve the disease,which is worthy of application and promotion.

关 键 词：原发性肝癌 多模式镇痛 HPOI评分 疼痛 血清结合珠蛋白 不良反应 

分 类 号：R735.7[医药卫生—肿瘤]