流通池法检测西吡氯铵含片的溶出度  

Dissolution Determination for Cetylpyridinium Chloride Buccal Tablets by Flow-through Cell Method

作　　者：刘延凤 王伟伟 陈晓杰 冯中 张贵民 LIU Yanfeng;WANG Weiwei;CHEN Xiaojie;FENG Zhon;ZHANG Guimin(Shandong New Time Pharmaceutical Co.,Ltd.,Linyi 273400;National Engineering Research Center of Chiral Drugs,Lunan Pharmaceutical Group,Linyi 273400;Shandong Pharmaceutical Internationalization Engineering Laboratory,Linyi 276006)

机构地区：[1]山东新时代药业有限公司,山东临沂273400 [2]鲁南制药集团股份有限公司,国家手性制药工程技术研究中心,山东临沂273400 [3]山东省药物国际化工程实验室,山东临沂276006

出　　处：《中国医药工业杂志》2024年第1期96-100,共5页Chinese Journal of Pharmaceuticals

摘　　要：采用流通池法检测西吡氯铵(1)含片的溶出度,并对溶出介质浓度、玻璃珠构建方式和用量、流通池流速进行了优化,同时使用建立的方法检测自制样品和参比样品的溶出曲线。结果显示,溶出介质浓度、玻璃珠用量对释放行为的影响不大,不同的玻璃珠构建方式和流通池流速对释放行为的影响较大。本法具有一定的可行性和区分能力,可用于评价1含片的体外溶出行为。The dissolution of cetylpyridinium chloride(1)buccal tablets was determined by flow-through cell method,and the concentration of the dissolution medium,the construction method and amount of glass beads,and the flow rate of the flow-through cell were optimized.Meanwhile,the dissolution curves of the self-made and reference samples were tested using the established method.The results showed that the concentration of the dissolution medium and the amount of glass beads had little effect on the release behavior,while different glass bead construction methods and flow rates of the flow-through cell had a significant effect on the release behavior.This method has certain feasibility and discriminatory ability,which can be used to evaluate the in vitro dissolution behavior of 1 buccal tablets.

关 键 词：流通池法 西吡氯铵 溶出度 

分 类 号：R927[医药卫生—药学]