八宝丹胶囊联合西药治疗湿热蕴结型急性黄疸型肝炎临床研究  

Clinical Study on Babaodan Capsules Combined with Western Medicine for Acute Icteric Hepatitis of Damp-Heat Accumulation Type

作　　者：谢燕娜 丁丰 XIE Yanna;DING Feng(Affiliated Hospital of Shaoxing University,Shaoxing Zhejiang 312000,China)

机构地区：[1]绍兴文理学院附属医院,浙江绍兴312000

出　　处：《新中医》2024年第4期63-67,共5页New Chinese Medicine

摘　　要：目的:观察八宝丹胶囊联合西药治疗湿热蕴结型急性黄疸型肝炎的临床疗效。方法:以220例湿热蕴结型急性黄疸型肝炎患者为研究对象,按随机数字表法分为研究组和对照组各110例。2组均予抗病毒、抗炎、保肝、降酶、退黄利胆等西药治疗,研究组加用八宝丹胶囊治疗,持续治疗4周。治疗前后评定中医证候评分,检测肝功能指标[谷草转氨酶(AST)、谷丙转氨酶(ALT)、γ谷氨酰转肽酶(γ-GT)、总胆汁酸(TBA)、总胆红素(TBil)],比较2组的临床疗效、中医证候疗效与不良反应发生率。结果:治疗后,研究组临床疗效总有效率和中医证候疗效总有效率均高于对照组(P<0.05)。2组AST、ALT、γ-GT、TBA、TBil水平均较治疗前下降(P<0.05)。研究组AST、ALT、γ-GT、TBA、TBil水平均低于对照组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:采用八宝丹胶囊联合西药治疗湿热蕴结型急性黄疸型肝炎,可有效提高临床疗效,缓解症状,促进肝功能恢复,且不增加用药安全性风险。Objective:To observe the clinical effect of the therapy of Babaodan Capsules combined with western medicine on acute icteric hepatitis of damp-heat accumulation type.Methods:A total of 220 patients with acute icteric hepatitis of damp-heat accumulation type were selected as the study subjects and divided into the study group and the control group according to the random number table method,with 110 cases in each group.The two groups were given western medicines for antiviral,antiinflammation,hepatoprotection,reducing enzyme,and treating jaundice and cholagogue,and the study group was additionally treated with Babaodan Capsules.The two groups were treated for 4 weeks.Before and after treatment,the traditional Chinese medicine(TCM)syndrome scores were evaluated;the levels of liver function indexes were detected,including aspartate aminotransferase(AST),alanine aminotransferase(ALT),γ-glutamyl transferase(γ-GT),total bile acid(TBA)and total bilirubin(TBil);the clinical effects,curative effects of TCM syndromes and incidence of adverse reactions were compared between the two groups.Results:After treatment,the total clinical effective rate and total effective rate of TCM syndromes in the study group were higher than those in the control group(P<0.05).The levels of AST,ALT,γ-GT,TBA and TBil in the two groups were decreased when compared with those before treatment(P<0.05),and the above levels in the study group were lower than those in the control group(P<0.05).There was no significant difference being found in the comparison of incidence of adverse reactions between the two groups(P>0.05).Conclusion:The therapy of Babaodan Capsules combined with western medicine can enhance the clinical effect on acute icteric hepatitis of damp-heat accumulation type,mitigate the symptoms,and promote the recovery of liver function with no increase in the medication safety risks.

关 键 词：急性黄疸型肝炎 湿热蕴结证 八宝丹胶囊 肝功能 

分 类 号：R575.1[医药卫生—消化系统]