IRF6在颅面部发育中的作用  

The Role of IRF6 in Craniofacial Development

作　　者：连奕琪 胡雪峰[1] 吕翼 LIAN Yiqi;HU Xuefeng;LÜYi(Fujian Key Laboratory of Developmental and Neurobiology,College of Life Sciences,Fujian Normal University,Fuzhou 350117,China)

机构地区：[1]福建师范大学生命科学学院/福建省发育与神经生物学重点实验室,福州350117

出　　处：《中国细胞生物学学报》2024年第2期300-307,共8页Chinese Journal of Cell Biology

基　　金：福建省自然科学基金(批准号:2021J05038);国家自然科学基金(批准号:81900535)资助的课题。

摘　　要：干扰素调节因子6(interferon regulatory factor 6, IRF6)是一种在胚胎发育过程中广泛表达的转录激活因子。研究发现, IRF6能够调控口腔上皮细胞的增殖与分化,影响唇腭的正常融合、牙釉质的形成以及牙齿形态,同时还参与颌骨成骨细胞的分化。IRF6基因的缺失或者突变会导致腭裂、牙齿缺失、颅面畸形、骨骼缺陷等颅面部异常。该文综述了IRF6在颅面部发育中的研究进展,旨在了解其在颅面部发育以及颅面畸形中的作用,以期为今后相关研究提供参考。IRF6(interferon regulatory factor 6)is a kind of transcriptional activator which has been widely expressed in embryonic development.IRF6 can control the growth and differentiation of oral epithelial cells and the epidermis,affect the normal fusion of lip and palate and affect the normal growth of the epidermis.It also plays a role in the differentiation of cranial and jaw osteoblasts.The deletion or mutation of the IRF6 gene leads to craniofacial abnormalities,such as cleft palate,tooth loss,craniofacial deformities and bone defects.In this review,the research progress of IRF6 in craniofacial development was reviewed,in order to understand the role of IRF6 in craniofacial development and craniofacial deformities,and to provide reference for future research on IRF6.

关 键 词：IRF6 唇腭裂 颅面部发育 颅面畸形 

分 类 号：R33[医药卫生—人体生理学]