丙戊酸钠辅助治疗小儿癫痫临床疗效及血清NSE、Hcy与T细胞17水平变化分析  

Analysis of the clinical effects and changes in serum NSE,Hcy and T cell 17 levels during the adjuvant treatment of epilepsy in children with sodium valproate

作　　者：柳敏[1] 程颖 景素敬 姜红[2] 郝伟红[2] LIU Min;CHENG Ying;JING Sujing;JIANG Hong;HAO Weihong(Department of Pediatrics,the Second Hospital of Handan City,Handan,Hebei,China,056000;Pediatrics Department of Handan Central Hospital,Handan,Hebei,China,056000)

机构地区：[1]邯郸市第二医院儿科,河北邯郸056000 [2]邯郸市中心医院儿科,河北邯郸056000

出　　处：《分子诊断与治疗杂志》2024年第2期212-215,共4页Journal of Molecular Diagnostics and Therapy

基　　金：河北中医药管理局科研计划项目(2023469)。

摘　　要：目的 分析丙戊酸钠辅助治疗小儿癫痫临床疗效及对血清神经元特异性烯醇化酶(NSE)、同型半胱氨酸(Hcy)及T细胞17水平(Th17)变化的影响。方法 选取2020年1月至2023年3月邯郸市第二医院收治的小儿癫痫患儿152例,根据治疗方案不同分为对照组73例(托吡酯)和观察组79例(丙戊酸钠+托吡酯)。比较两组总疗效率、炎性因子[肿瘤坏死因子-α(TNF-α)、白介素-2(IL-2)、Hcy]、脑源性神经营养因子(BDNF)、NSE、Th17水平及不良反应。结果 观察组总疗效率为91.81%,对照组总疗效率为75.29%,观察组总疗效率高于对照组,差异有统计学意义(P<0.05)。两组治疗后TNF-α、IL-2、NSE、Hcy、Th17水平均下降,且观察组TNF-α、IL-2、NSE、Hcy、Th17水平低于对照组,差异有统计学意义(P<0.05)。两组治疗后BDNF水平均上升,且观察组BDNF水平高于对照组,差异有统计学意义(P<0.05)。对照组及观察组不良反应总发生率分别为9.59%、5.04%,两组不良反应总发生率比较差异无统计学意义(P>0.05)。结论 丙戊酸钠辅助托吡酯治疗小儿癫痫临床疗效较为理想,可有效减轻炎症反应,显著降低NSE、Th17水平。Objective To analyze the clinical effect of sodium valproate in the adjuvant treatment of children with epilepsy,as well as its impact on the changes in serum neuron specific enolase(NSE),homo-cysteine(Hcy)and T cell 17 level(Th17).Methods A total of 152 children with epilepsy were admitted to Handan Second Hospital from January 2020 to March 2023.They were selected for the study and divided into two groups based on their treatment regimens:acontrol group of 73 cases(treated with topiramate)and an ob-servation group of 79 cases(treated with sodium valproate+topiramate).Thestudy compared the overall effi-cacy rate,levels of inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-2(IL-2),Hcy],brain-derived neurotrophic factor(BDNF),NSE,Th17 levels and adverse reactions between the two groups.Results The total curative effect rate of the control group was 75.29%,while the observation group had a higher rate of 91.81%.This difference was statistically significant(P<0.05).After treatment,both groups showed a decrease in the levels of TNF-α,IL-2,NSE,Hcy and Th17.The observation group had lower levels of these markers compared to the control group,and this difference was statistically significant(P<0.05).The level of BDNF increased in both groups after treatment,with the observation group having a higher level than the control group.This difference was statistically significant(P<0.05).The total incidence of adverse reac-tions in the control group was 9.59%,while the observation group had a lower rate of 5.04%.However,this difference was not statistically significant(P>0.05).Conclusion The clinical efficacy of sodium valproate as-sisted topiramate in the treatment of children with epilepsy is excellent.This combination effectively reduces in-flammation and significantly lowers the levels of NSE and Th17.

关 键 词：丙戊酸钠 小儿癫痫 神经元特异性烯醇化酶 同型半胱氨酸 T细胞17水平 

分 类 号：R742.1[医药卫生—神经病学与精神病学]