溶骨性骨代谢标志物血Ⅰ型CTP、miR-107及TRACP-5b检测在肺癌骨转移中的诊断价值  

The diagnostic value of osteolytic bone metabolism markersⅠCTP,miR⁃107 and TRACP⁃5b detection in lung cancer bone metastasis

作　　者：康翠伟 闫利鹏 刘宁 贾向波 KANG Cuiwei;YAN Lipeng;LIU Ning;JIA Xiangbo(Department of Anesthesiology and Perioperative Medicine,Henan Provincial Key Medicine Laboratory of Nursing,Henan Provincial People's Hospital,Zhengzhou University People's Hospital,Zhengzhou,Henan,China,450000;Department of Thoracic Surgery,Henan Provincial People's Hospital,Zhengzhou,Henan,China,450000)

机构地区：[1]河南省人民医院麻醉与围术期医学科,河南省护理医学重点实验室,郑州大学人民医院,河南郑州450000 [2]河南省人民医院胸外科,河南郑州450000

出　　处：《分子诊断与治疗杂志》2024年第2期331-334,共4页Journal of Molecular Diagnostics and Therapy

基　　金：河南省科技发展计划(232102310044)。

摘　　要：目的 分析血Ⅰ型胶原交联羧基末端肽(ⅠCTP)、微小RNA-107(miR-107)、血抗酒石酸酸性磷酸酶5b(TRACP-5b)检测在肺癌骨转移中的诊断效果。方法 选取2020年10月至2022年12月于河南省人民医院医治的中晚期肺癌患者122例,根据是否发生骨转移分为骨转移组58例、非骨转移组64例。比较骨转移组、非骨转移组ⅠCTP、miR-107、TRACP-5b水平。比较骨转移组病灶不同分级ⅠCTP、miR-107、TRACP-5b水平。比较骨转移组不同骨转移累及数目ⅠCTP、miR-107、TRACP-5b水平。分析ⅠCTP、miR-107、TRACP-5b对肺癌骨转移的诊断效能。结果 骨转移组ⅠCTP、miR-107、TRACP-5b水平均高于非骨转移组,差异具有统计学意义(P<0.05)。ⅠCTP、miR-107、TRACP-5b水平:Ⅲ~Ⅳ级>Ⅰ~Ⅱ级>0级,差异具有统计学意义(P<0.05)。≥3处以上转移组ⅠCTP、miR-107、TRACP-5b水平高于≤2处转移组,差异具有统计学意义(P<0.05)。ⅠCTP、miR-107、TRACP-5b联合诊断肺癌骨转移灵敏度为96.42%,特异度为93.93%,准确度为95.08%,均高于上述指标单一检查(P<0.05)。结论 ⅠCTP、miR-107、TRACP-5b水平与肺癌骨转移发生具有紧密关联,其中TRACP-5b检测肺癌骨转移灵敏度、特异度及准确度最高,三者联合检测可有效提高肺癌骨转移诊断价值。Objective To analyze the diagnostic value of serum type I collagen cross-linked car-boxyl terminal peptide(ⅠCTP),miR-107 and tartrate-resistant acid phosphatase 5b(TRACP-5b)detection in bone metastasis of lung cancer.Methods A total of 122 patients with advanced lung cancer treated at Henan Provincial People's Hospital from October 2020 to December 2022 were divided into two groups:the bone me-tastasis group(58 cases)and the non-bone metastasis group(64 cases)based on the presence of bone metasta-sis.The study consisted of four parts:Comparison of CTP,miR-107,and TRACP-5b levels between the bone metastasis group and the non-bone metastasis group.Comparison of CTP,miR-107,and TRACP-5b levels within the bone metastasis group.Comparison of the number of different bone metastasis group and the levels of CTP,miR-107,and TRACP-5b were compared.Analysis of the diagnostic value of CTP,miR-107,and TRACP-5b in bone metastasis of lung cancer.Results The levels of CTP,miR-107,and TRACP-5b in the bone metastasis groupⅠwere higher than those in the non-bone metastasis group,and the differences were sta-tistically significant(P<0.05).The levels ofⅠCTP,miR-107,and TRACP-5b:were higher in stagesⅢ-Ⅳcompared to stagesⅠ-Ⅱand 0,and the difference was statistically significant(P<0.05).The levels of CTP,miR-107,and TRACP-5b were higher in the≥3 metastasis groups compared to the≤2 metastasis groups,and the difference was statistically significant(P<0.05).The sensitivity,specificity,and accuracy of ICTP,miR-107,and TRACP-5b in diagnosing bone metastasis of lung cancer were 96.42%,93.93%and 95.08%re-spectively,which were higher than those of the individual indercator,and the difference was statistically sig-nificant(P<0.05).Conclusion The levels of CTP,miR-107,and TRACP-5b are closely associated with the occurrence of lung cancer bone metastasis.TRACP-5b has the highest sensitivity,specificity,and accuracy in detecting lung cancer bone metastasis.The combined detection of the three can effectively improve the diagnos-tic

关 键 词：型胶原交联羧基末端肽 微小RNA-107 抗酒石酸酸性磷酸酶5B 肺癌 骨转移 

分 类 号：R734.2[医药卫生—肿瘤]