巨噬细胞中Piezo1调控铁代谢在年龄相关骨量丢失中的研究  

Research on the regulation of iron metabolism in age⁃related bone loss by Piezo1 in macrophages

作　　者：陈楚仪 何琪 杨均政 曾嘉旭 陈柏豪 池伟进 肖嘉聪 潘兆丰 黎淼 黎少聪 林跃玮 王璠琛 谢辉 王海彬[3] 陈鹏[3] CHEN Chuyi;HE Qi;YANG Junzheng;ZENG Jiaxu;CHEN Baihao;CHI Weijin;XIAO Jiacong;LI Miao;LI Shaocong;LIN Yuewei;WANG Fanchen;XIE Hui;WANG Haibin;CHEN Peng(The First Clinical College of Guangzhou Traditional Chinese Medical University,Guangzhou 510405,China;The First Zone of Department of Bone Trauma,Shenzhen Traditional Chinese Medical Hospital,Shenzhen 518033,China;Department of Orthopedics,Guangzhou Traditional Chinese Medical University,Guangzhou 510405,China)

机构地区：[1]广州中医药大学第一临床医学院,广东广州510405 [2]深圳市中医院骨伤科一病区,广东深圳518033 [3]广州中医药大学第一附属医院骨科,广东广州510405

出　　处：《中国骨质疏松杂志》2024年第3期355-359,共5页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金面上项目(82374470);国家自然科学基金青年项目(82104887)。

摘　　要：目的对Piezo1蛋白在巨噬细胞参与铁代谢平衡调控中作用作一综述,总结近年来关于年龄相关骨量丢失及巨噬细胞Piezo1的最新研究进展,为治疗年龄相关骨量丢失提供新思路。方法计算机检索CNKI、PubMed等数据库自建库至2023年1月与巨噬细胞Piezo1在年龄相关骨量丢失的相关文献,中文检索关键词为“巨噬细胞、机械敏感性离子通道蛋白、年龄相关骨量丢失、骨质疏松症”,英文检索关键词为“Macrophages、Piezo1、age⁃related bone loss、ARBL、Osteoporosis”,最终将42篇文献纳入。结果与结论巨噬细胞参与铁代谢平衡的调控,骨髓巨噬细胞中Piezo1高表达能导致机体出现铁超载,进而导致ARBL的发生。Piezo1为治疗年龄相关骨量丢失提供了分子层面的新思路和新视角。Objective To review the role of Piezo1 protein in macrophages in the regulation of homeostasis of iron metabolism,to summarize the latest advances in age⁃related bone loss(ARBL)and macrophage Piezo1,and to provide new ideas for the treatment of age⁃related bone loss.Methods The literature related to macrophage Piezo1 in age⁃related bone loss was screened in CNKI,

关 键 词：骨量丢失 巨噬细胞 Piezo1蛋白 铁代谢 

分 类 号：R363[医药卫生—病理学]