P53 together with ferroptosis: a promising strategy leaving cancer cells without escape  

作　　者：Jianhao Zhan Jisheng Wang Yuqing Liang Xiaoping Zeng Enliang Li Hongmei Wang 

机构地区：[1]Department of General Surgery,Second Affiliated Hospital of Nanchang University,Nanchang 330006,China [2]HuanKui Academy,Nanchang University,Nanchang 330006,China [3]School of Basic Medical Sciences,Nanchang University,Nanchang 330006,China [4]Medical College,Jinhua Polytechnic,Jinhua 321017,China

出　　处：《Acta Biochimica et Biophysica Sinica》2024年第1期1-14,共14页生物化学与生物物理学报（英文版）

基　　金：This work was supported by the grants from the National Natural Science Foundation of China(Nos.82060526 and 81860540 to H.W.,and No.82260553 to E.L.);the Jiangxi Provincial Natural Science Foundation(No.20224BAB206068 to H.W.and No.20224BAB216057 to E.L.).

摘　　要：TP53,functioning as the keeper of the genome,assumes a pivotal function in the inhibition of tumorigenesis.Recent studies have revealed that p53 regulates ferroptosis pathways within tumor cells and is closely related to tumorigenesis.Therefore,we summarize the pathways and mechanisms by which p53 regulates ferroptosis and identify a series of upstream and downstream molecules involved in this process.Furthermore,we construct a p53-ferroptosis net-work centered on p53.Finally,we present the progress of drugs to prevent wild-type p53(wtp53)degeneration and restore wtp53,highlighting the deficiencies of drug development and the prospects for p53 in cancer treatment.These findings provide novel strategies and directions for future cancer therapy.

关 键 词：P53 ferroptosis lipid peroxidation ferroptosis signaling cancer therapy 

分 类 号：R730.5[医药卫生—肿瘤]