Evaluation of the protective effect of salidroside on arsenic-induced cardiac dysfunction in rats  

作　　者：Ruimeng Tian Jing Cheng Yanna Wang Chuncui Chen Lei Huang Caiyun Zhang Yifei Zhou Shanshan Dong Guilin Lu Wenjuan Qin 

机构地区：[1]Department of Ultrasonography,the First Affiliated Hospital,Shihezi University,Shihezi 832008,China

出　　处：《Acta Biochimica et Biophysica Sinica》2024年第1期140-143,共4页生物化学与生物物理学报（英文版）

基　　金：This work was supported by the grants from the National Natural Science Foundation of China(No.82160338);the Youth Innovation and Talent Training Project of Shihezi University(No.CXPY202008);the School-level Scientific Research Projects supported by Shihezi University(Nos.ZZZC202196 and ZZZC2022091);the College-level Project of the First Affiliated Hospital of Medical College of Shihezi University(No.QN202127);Corps Science and Technology Plan Project(No.KY000109).

摘　　要：Arsenic is a natural metal found in nature.Excessive intake of arsenic in the human body can lead to acute and chronic arsenic poisoning and even induce various diseases,such as cancers[1].According to statistics,approximately 200 million people worldwide are exposed to the toxic effects of arsenic[2].Previous studies showed that in the case of arsenic poisoning,arsenic could induce cells to produce excessive reactive oxygen species(ROs)through oxidative stress pathways,promote inflammatory reactions,and cause myocardial cell damage,leading to dysfunction of the heart[3,4].Salidroside(Sal)has been proven to have various pharmacological activities,such as anti-inflammatory,antioxidant,anticancer,antimetabolic disorders,and neuroprotective effects[5].In recent years,the cardiovascular protective effect of Sal has received attention and has been used to treat various cardiovascular diseases[6].

关 键 词：protective CARDIOVASCULAR DISEASES 

分 类 号：R54[医药卫生—心血管疾病] R28[医药卫生—内科学]