液相色谱-串联质谱法检测动物源性食品中糖皮质激素类药物的残留  

Determination of Glucocorticoid Residues in Foods of Animal Origin by Liquid Chromatography-Tandem Mass Spectrometry

作　　者：康宗华 周雨洁 KANG Zonghua;ZHOU Yujie(Hunan Kouweiwang Group Co.,Ltd.,Yiyang 413000,China;Hunan Tuopu Inspection Institute,Yiyang 413000,China)

机构地区：[1]湖南口味王集团有限责任公司,湖南益阳413000 [2]湖南拓谱检测技术有限公司,湖南益阳413000

出　　处：《食品安全导刊》2024年第4期59-61,共3页China Food Safety Magazine

摘　　要：目的:利用液相色谱-串联质谱法检测动物源性食品中糖皮质激素类药物的残留。方法:将组织样品进行碱水解后,用乙酸乙酯提取。使用高效液相色谱-串联质谱仪分析,采用电喷雾离子源,正离子扫描。结果:本方法线性关系良好,相关系数均大于0.99,加标回收率为72.95%~99.86%。结论:该方法可用于动物源性食品中糖皮质激素类药物残留的检测,简单灵敏,准确度高。Objective:To detect the residues of glucocorticoids in animal-derived foods by liquid chromatography-tandem mass spectrometry.Method:After alkaline hydrolysis,the tissue samples were extracted with ethyl acetate.Using high performance liquid chromatography-tandem mass spectrometry analysis,using electrospray ion source,positive ion scanning.Result:The linear relationship of this method was good,the correlation coefficient was greater than 0.99,and the recovery rate was 72.95%~99.86%.Conclusion:This method can be used for the detection of glucocorticoid drug residues in animal-derived foods,which is simple,sensitive and accurate.

关 键 词：液相色谱-串联质谱法 糖皮质激素类 药物残留 

分 类 号：O657.63[理学—分析化学] TS207.3[理学—化学]