四维CT联合四维锥形束CT在肺癌立体定向放射治疗中的应用研究进展  

Research progress on the application of four-dimensional CT combined with four-dimensional cone beam CT in stereotactic radiotherapy for lung cancer

作　　者：刘欣 张菲菲 段诗苗[1] Liu Xin;Zhang Feifei;Duan Shimiao(Department of Radiotherapy,The First Affiliated Hospital of Bengbu Medical College,Bengbu 233004,China;Graduate School,Bengbu Medical College,Bengbu 233030,China)

机构地区：[1]安徽省蚌埠医学院第一附属医院放射治疗科,蚌埠233004 [2]蚌埠医学院研究生院,蚌埠233030

出　　处：《中国医学装备》2024年第3期159-166,共8页China Medical Equipment

基　　金：安徽省呼吸系统疾病(肿瘤)临床医学研究中心(2020b07030008)。

摘　　要：以立体定向放射治疗(SBRT)为代表的高精度放射治疗在肺癌治疗的各个阶段发挥重要作用,而医学影像技术的进步、更加精确的剂量计算方法以及先进的影像及剂量验证算法的应用则为高精准放射治疗的实现提供保证。四维CT(4D CT)能够较好的显示肿瘤受呼吸影响的个体化运动,四维锥形束CT(4D-CBCT)作为勾画并获得肿瘤内靶区(ITV)的一种图像引导技术(IGRT),可以为实现精准治疗提供保证,上述两种技术结合能够纠正位移误差,实施监测肿瘤的运动范围并确保运动的靶区在照射范围内,是实施SBRT的保证。以肺癌精确放射治疗应用研究中的IGRT为切入点,综述4D CT联合4D-CBCT在肿瘤SBRT中的临床应用价值,旨在为肺癌的临床放射治疗提供参考。High-precision radiotherapy represented by stereotactic body radiation therapy(SBRT)plays an important role in every stage of lung cancer treatment.The development of medical imaging technology,more accurate dose calculation methods,and the application of advanced imaging and dose verification algorithms provide guarantee for the realization of high-precision radiotherapy.Four-dimensional computed tomography(4D CT)can better display the individualized motion of tumors affected by respiration.Four-dimensional cone beam computed tomography(4D-CBCT)is an image-guided technology to delineate and obtain the internal target volume(ITV),which Can provide guarantee for precise treatment.The combination of the two technologies can correct the displacement error,monitor the range of tumor motion,and ensure that the moving target is within the irradiation range,which is the guarantee of stereotactic radiotherapy.From the perspective of image-guided radiation technology in the application of precise radiotherapy for lung cancer,the clinical application value of 4D CT combined with 4D-CBCT in SBRT of tumors was reviewed,aiming to provide reference for clinical radiotherapy of lung cancer.

关 键 词：四维锥形束CT(4D-CBCT) 四维CT(4D CT) 肺癌 图像引导的调强放射治疗 剂量学 

分 类 号：R734.2[医药卫生—肿瘤]