环周预切开内镜黏膜切除术治疗直径小于1 cm的直肠神经内分泌肿瘤的有效性和安全性  

The effectiveness and safety of endoscopic mucosal resection with precutting for rectal neuroendocrine neoplasm smaller than 1 cm in diameter

作　　者：石磊[1] 赵元顺[1] 张浩[1] 钱晶瑶 杨潇 李文[1] 张姝翌[1] Shi Lei;Zhao Yuanshun;Zhang Hao;Qian Jingyao;Yang Xiao;Li Wen;Zhang Shuyi(Department of Endoscopy,Tianjin Union Medical Center,Tianjin 300121,China)

机构地区：[1]天津市人民医院内镜诊疗中心,天津300121

出　　处：《中国内镜杂志》2024年第3期1-6,共6页China Journal of Endoscopy

基　　金：中华人民共和国科技部国家重点研发计划(No:2022YFC3602105)。

摘　　要：目的探讨环周预切开内镜黏膜切除术(EMR-P)治疗直径小于1 cm的直肠神经内分泌肿瘤(RNEN)的有效性和安全性。方法回顾性分析2016年12月-2021年12月该院收治的177例直径<1 cm的RNEN患者的临床资料,根据治疗方案的不同,将患者分为内镜黏膜切除术(EMR)组(n=46)、EMR-P组(n=40)和内镜黏膜下剥离术(ESD)组(n=91),比较3组患者整块切除率、完整切除率、内镜下手术时间、术后住院时间和手术并发症等情况。结果EMR-P组完整切除率为95.0%,ESD组完整切除率为97.8%,高于EMR组的87.0%,差异有统计学意义(P<0.05);EMR-P组手术时间为(9.86±2.23)min,长于EMR组的(4.12±0.88)min,EMR-P组和EMR组手术时间短于ESD组的(19.55±3.67)min,差异均有统计学意义(P<0.05);EMR组住院时间为(2.45±0.29)d,EMR-P组住院时间为(2.43±0.23)d,EMR-P组和EMR组住院时间短于ESD组的(3.30±0.32)d,差异均有统计学意义(P<0.05);3组患者整块切除率和并发症发生率比较,差异均无统计学意义(P>0.05)。结论EMR-P用于治疗直径<1 cm的RNEN,操作简单,手术时间和住院时间短,且组织学完整切除率高,并发症发生率低,值得临床应用。Objective To investigate the effectiveness and safety of endoscopic mucosal resection with precutting(EMR-P)for the treatment of rectal neuroendocrine neoplasm(RNEN)smaller than 1 cm in diameter.Methods Clinical data of 177 patients with RNEN smaller than 1 cm in diameter from December 2016 to December 2021 were retrospectively analyzed.According to different treatment protocols,177 patients with RNEN were divided into endoscopic mucosal resection(EMR)group(n=46),EMR-P group(n=40)and endoscopic submucosal dissection(ESD)group(n=91).The en bloc resection rate,complete resection rate,operation time,postoperative hospitalization time and incidence of operative complications among the three groups were compared.Results The complete resection rate in the EMR-P group(95.0%)and ESD group(97.8%)were significantly higher than that in the EMR group(87.0%)(P<0.05);The operation time in the EMR-P group(9.86±2.23)min was longer than that in the EMR group(4.12±0.88)min,EMR-P group and EMR group were shorter than that in the ESD group(19.55±3.67)min,the difference was statistically significant(P<0.05);Postoperative hospitalization time in the EMR group was(2.45±0.29)d and EMR-P group was(2.43±0.23)d,which were shorter than that in the ESD group(3.30±0.32)d,and the difference was statistically significant(P<0.05).There were no significant difference in the rates of en bloc resection and operative complications among the three groups(P>0.05).Conclusion EMR-P for the treatment of RNEN<1 cm in diameter has the advantages,such as simple operation,short operation time and hospitalization time,high histological complete resection rate and low complication rate,which is worthy of clinical application.

关 键 词：直肠神经内分泌肿瘤(RNEN) 环周预切开内镜黏膜切除术(EMR-P) 内镜黏膜切除术(EMR) 内镜黏膜下剥离术(ESD) 治疗方法 

分 类 号：R735.37[医药卫生—肿瘤]