构建6H-1,3-噁嗪-6-酮的研究进展  

Research Progress on the Construction of 6 H-1,3-Oxazine-6-One

作　　者：周淑晶[1] 柳召宁 洛雪 孙立娇 黄姗珊 李进京[1] ZHOU Shu-jing;LIU Zhao-ning;LUO Xue;SUN Li-jiao;HUANG Shan-shan;LI Jin-jing(College of Pharmacy,Jiamusi University,Jiamusi 154007,China)

机构地区：[1]佳木斯大学药学院,黑龙江佳木斯154007

出　　处：《化学试剂》2024年第4期11-20,共10页Chemical Reagents

基　　金：黑龙江省自然科学基金项目(LH2022H094)。

摘　　要：6H-1,3-噁嗪-6-酮是一类重要的杂环化合物,广泛应用于有机合成、精细化工和医药领域,且在抗肿瘤、抗疟疾、抗真菌活性等方面都表现出优异的性能,故备受有机合成工作者的关注。近年来,6H-1,3-噁嗪-6-酮骨架的构筑方法和策略取得了长足发展。尤其是通过过渡金属催化机理的偶联反应得到迅速发展。因此,很有必要对其进行梳理。经查阅文献目前尚无相关专题综述对构建6H-1,3-噁嗪-6-酮的合成进行归纳总结,故对6H-1,3-噁嗪-6-酮骨架的构建方法进行详细综述,以期为类似化合物的合成方法提供新思路。6 H-1,3-oxazine-6-one is a significant heterocyclic compound with wide applications in organic synthesis,the fine chemical industry,and medicine.It exhibits excellent properties in anti-tumor,anti-malaria,and anti-fungal activities,making it a subject of great interest in organic synthesis.In recent years,substantial progress has been made in the construction methods and strategies for the 6 H-1,3-oxazine-6-one backbone,particularly through coupling reactions utilizing transition metal catalysis.However,there is currently no comprehensive review available that summarizes the synthesis of 6 H-1,3-oxazine-6-one.Therefore,this review aims to provide a detailed overview of the construction methods employed for the 6 H-1,3-oxazine-6-one backbone,with the intention of offering new insights and ideas for the synthesis of similar compounds.

关 键 词：噁嗪酮 过渡金属 合成方法 反应机理 研究进展 

分 类 号：O624.6[理学—有机化学]