口腔主动健康与肥胖  

Oral Proactive Healthcare and Obesity

作　　者：崔靖 杜函泽 翟文昊 温琳琳 黄蕾[1] 陈适 李道伟[1] 潘慧 CUI Jing;DU Hanze;ZHAI Wenhao;WEN Linlin;HUANG Lei;CHEN Shi;LI Daowei;PAN Hui(Norman Bethune Stomatological School of Jilin University,Chuangchun 130021,China;Department of Endocrinology,Key Laboratory of Endocrinology,National Health Commission of the People's Republic of China,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China)

机构地区：[1]吉林大学白求恩口腔医学院,长春130021 [2]中国医学科学院北京协和医院内分泌科,国家卫生健康委员会内分泌重点实验室,北京100730

出　　处：《协和医学杂志》2024年第2期450-455,共6页Medical Journal of Peking Union Medical College Hospital

基　　金：国家重点研发计划(2022YFC3600203)。

摘　　要：口腔健康与全身健康息息相关。常见的口腔慢性疾病,如牙周炎和根尖周炎,一方面可影响牙槽骨和牙龈等口腔软硬组织健康,另一方面还可能引起全身慢性低度炎症、氧化应激水平升高和菌群失调等全身症状,而这些全身健康状况的改变可加剧肥胖进展。因此,通过口腔主动健康干预,如保持良好的口腔卫生习惯、改变饮食结构、主动寻求口腔检查等,不仅可有效预防和治疗口腔炎症性疾病,还可能通过改善全身健康状态从而解决肥胖问题。本文深入探讨口腔炎症性疾病对肥胖的影响及其内在机制,定义了“口腔主动健康”概念,并系统总结其对口腔炎症性疾病的防治作用,讨论通过口腔主动健康策略改善肥胖的可能性。Oral health is closely related to systemic health.Common chronic oral diseases,periodontitis and periapical inflammation for example,not only affect the health of oral soft and hard tissues including the alveolar bone and gums,but may also cause changes in systemic conditions such as chronic low⁃grade inflamma⁃tion,elevated oxidative stress levels,and dysbiosis of the microbiota.These changes in systemic health can ex⁃acerbate the progression of obesity.Therefore,through proactive oral health interventions such as maintaining good oral hygiene habits,modifying dietary structures,and undergoing oral examinations,it is possible to effec⁃tively prevent and alleviate inflammatory oral diseases,and actively intervene in obesity.This article delves into the impact of inflammatory oral diseases on obesity and their underlying mechanisms,defines the concept of“oral proactive healthcare”,and systematically summarizes their preventive and therapeutic effects on in⁃flammatory oral diseases,thereby demonstrating the potential of improving obesity through proactive oral health strategies.

关 键 词：口腔主动健康 肥胖 牙周炎 根尖周炎 慢性低度炎症 

分 类 号：R78[医药卫生—口腔医学] R1[医药卫生—临床医学] R58