紫外线联合康复新液、氧疗用于化疗后口腔黏膜炎的效果  

Effects of ultraviolet combined with Kangfuxin liquid and oxygen therapy on post chemotherapy oral mucositis

作　　者：谢兆勤 漆晓芹 吴晶晶[1] 陈思[1] 冯沙沙 沈艳秋 Xie Zhaoqin;Qi Xiaoqin;Wu Jingjing;Chen Si;Feng Shasha;Shen Yanqiu(Department of Hematology,the Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University,Huai'an 223300,China)

机构地区：[1]南京医科大学附属淮安第一医院血液科,淮安223300

出　　处：《中华现代护理杂志》2024年第9期1223-1227,共5页Chinese Journal of Modern Nursing

基　　金：江苏省淮安市自然科学研究计划(HAB202205)。

摘　　要：目的探究短波紫外线(UV-C)联合康复新液湿敷、氧气吹拂法治疗血液肿瘤患者化疗后口腔黏膜炎(OM)的效果。方法采用便利抽样法, 选取2022年1月—2023年2月在南京医科大学附属淮安第一医院血液科血液肿瘤化疗后出现OM的患者120例, 随机分为对照组和观察组, 各60例。对照组单用康复新液湿敷, 观察组在对照组基础上联合使用UV-C照射加氧气口腔吹拂法。比较分析两组患者治疗前、治疗2 d后视觉模拟评分法(VAS)疼痛评分、第5天治疗结束后OM愈合情况以及两组患者OM愈合时间。结果最终共108例患者完成研究, 对照组52例, 观察组56例。两组患者治疗2 d后VAS疼痛评分皆低于治疗前, 且观察组低于对照组, 差异有统计学意义(P<0.05);第5天治疗结束后观察组OM愈合率高于对照组, 差异有统计学意义(χ^(2)=5.425, P<0.05);观察组OM愈合时间短于对照组, 差异有统计学意义(t=2.458, P<0.05)。结论 UV-C联合康复新液、氧气吹拂法治疗血液肿瘤化疗后OM能够缓解患者疼痛、提高OM的痊愈率、缩短OM痊愈时间, 值得临床推广。Objective To explore the effect of ultraviolet-C(UV-C)combined with Kangfuxin liquid wet compress and oxygen blowing method on the post chemotherapy oral mucositis(OM)in patients with hematological malignancies.Methods From January 2022 to February 2023,convenience sampling was used to select 120 patients with post chemotherapy OM in the Department of Hematology of the Affiliated Huai'an First People's Hospital of Nanjing Medical University.The patients were randomly divided into a control group and an observation group,with 60 cases in each group.The control group received Kangfuxin liquid wet compress,while the observation group carried out a combination of UV-C irradiation and oxygen oral blowing method on the basis of the control group.This study compared the Visual Analogue Scale(VAS)score before and two days after treatment,the healing status of OM after treatment on the 5th day,and the healing time of OM between the two groups of patients.Results A total of 108 patients completed the study,with 52 in the control group and 56 in the observation group.After two days of treatment,the VAS scores of both groups of patients were lower than those before treatment,and those of the observation group were lower than those of the control group,with statistically significant differences(P<0.05).On the 5th day of treatment,the healing rate of OM in the observation group was higher than that in the control group,and the difference was statistically significant(χ^(2)=5.425,P<0.05).The healing time of OM in the observation group was shorter than that in the control group,and the difference was statistically significant(t=2.458,P<0.05).Conclusions The combination of UV-C,Kangfuxin liquid and oxygen blowing method can alleviate pain,improve the healing rate of OM,and shorten the healing time of post chemotherapy OM in patients with hematological malignancies,which is worthy of clinical promotion.

关 键 词：化学疗法 血液肿瘤 口腔黏膜炎 康复新液湿敷 氧气吹拂法 短波紫外线 

分 类 号：R733[医药卫生—肿瘤] R781.5[医药卫生—临床医学]