脑小血管病患者膀胱过度活动症的影响因素分析  

Influencing factors for over active bladder syndrome in patients with cerebral small vessel disease

作　　者：冯彩霞[1] 王增帅[2] 刘雪齐 温敏 Feng Caixia;Wang Zengshuai;Liu Xueqi;Wen Min(Department of Neurology,the Second Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014030,Inner Mongolia Autonomous Region,China)

机构地区：[1]内蒙古科技大学包头医学院第二附属医院神经内科,包头014030 [2]内蒙古科技大学包头医学院第二附属医院心血管内科,包头014030

出　　处：《中华老年心脑血管病杂志》2024年第3期297-300,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：内蒙古自治区自然科学基金项目(2019MS08203,2021LHS08011);包头市卫生健康科技计划项目(wsjkkj2022114)。

摘　　要：目的 探讨脑小血管病(CSVD)患者膀胱过度活动症(OAB)的影响因素及其与CSVD影像学标志物的相关性。方法 选取2021年1月至2022年12月于包头医学院第二附属医院就诊的老年CSVD患者163例,依据OAB评分量表评估分为OAB组37例和非OAB组126例。记录并比较2组患者简易智能状态检查量表(MMSE)评分、Fazekas量表评分、CSVD影像学总负荷评分。结果 与非OAB组比较,OAB组年龄、尿频、夜尿、尿急、急迫性尿失禁比例、Fazekas量表评分、脑室旁白质高信号(PWMH)评分、脑深部白质高信号(DWMH)评分、CSVD总负荷评分显著增高,MMSE评分显著降低(P<0.05,P<0.01)。PWMH评分、DWMH评分是OAB发生的危险因素(P<0.01)。CSVD患者OAB评分量表评分与Fazekas量表评分、PWMH评分、DWMH评分呈正相关(r=0.533,P=0.001;r=0.462,P=0.004;r=0.398,P=0.015);CSVD患者急迫性尿失禁的发生与Fazekas量表评分、PWMH评分呈正相关(r=0.352,P=0.033;r=0.346,P=0.036)。结论 PWMH、DWMH是CSVD患者OAB的危险因素。Objective To explore the influencing factors of over active bladder(OAB)in patients with cerebral small vessel disease(CSVD)and its correlation with CSVD imaging markers.Meth-ods A total of 163elderly CSVD patients admitted in our hospital from January 2021to Decem-ber 2022were enrolled and divided into OAB group(37cases)and non-OAB group(126cases)based on the results of OAB rating scale.Mini-mental State Examination(MMSE)score,Fazekas scale score,and total CSVD burden score were recorded and compared between the two groups.Results The OAB group had older age,higher urinary frequency,larger proportions of nocturia,urgency,and urge incontinence ratio,increased Fazekas score,periventricular white matter hyper-intensity(PWMH)score and deep white matter hyperintensity(DWMH)score,and elevated total CSVD burden score and lower MMSE score than the non-OAB group(P<0.05,P<0.01).PWMH score and DWMH score were risk factors for the occurrence of OAB(P<0.01).The OAB score was positively correlated with Fazekas score,PWMH score,and DWMH score in the CSVD patients(r=0.533,P=0.001;r=0.462,P=0.004;r=0.398,P=0.015).The occurrence of urgency urinary incontinence was positively correlated with Fazekas score and PWMH score in the CSVD patients(r=0.352,P=0.033;r=0.346,P=0.036).Conclusion PWMH and DWMH are risk factors for OAB occurrence in CSVD patients.

关 键 词：大脑小血管疾病 膀胱 过度活动性 磁共振血管造影术 磁共振成像 危险因素 脑室旁白质高信号 

分 类 号：R743[医药卫生—神经病学与精神病学] R694.5[医药卫生—临床医学]