肾透明细胞癌组织中NSUN2的表达及其与临床病理特征和预后的关系  

Relationship between NSUN2 expression and clinicopathological features and prognosis in renal clear cell carcinoma

作　　者：张媛 胡文兵[2] 周蔷 杜天幸 ZHANG Yuan;HU Wenbing;ZHOU Qiang;DU Tianxing(Medical College,Wuhan University of Science and Technology,Hubei Wuhan 430081,China;Department of Oncology,Huangshi Central Hospital(Affiliated Hospital of Hubei Institute of Technology)Hubei Key Laboratory of Kidney Disease Intervention and Occurrence,Hubei Huangshi 435000,China)

机构地区：[1]武汉科技大学医学部医学院,湖北武汉430081 [2]黄石市中心医院(湖北理工学院附属医院)肿瘤内科肾脏疾病干预与发生湖北省重点实验室,湖北黄石435000

出　　处：《现代肿瘤医学》2024年第7期1295-1298,共4页Journal of Modern Oncology

基　　金：湖北省重点实验室开放基金项目(编号:SB202104)。

摘　　要：目的:检测NSUN2在肾透明细胞癌(ccRCC)组织中的表达,分析其与临床病理特征、预后之间的关系。方法:收集ccRCC组织蜡块标本及对应的癌旁组织蜡块标本各95例,采用免疫组化法检测NSUN2在两组标本中的表达水平,分析NSUN2与ccRCC患者的临床病理特征关系。采用Kaplan-Meier法绘制生存曲线,使用Log-rank检验进行单因素生存分析,Cox回归模型进行多因素生存分析,分析NSUN2表达与ccRCC患者预后之间的相关性。结果:NSUN2在癌组织的高表达率为69.5%,在癌旁组织中的高表达率为15.8%,两组差异有统计学意义(P<0.05)。NSUN2高表达与肿瘤大小(P<0.05)、组织学分级(P<0.05)、淋巴转移(P<0.05)及临床分期有关(P<0.05)。Kaplan-Meier分析显示,NSUN2表达水平与ccRCC患者预后相关(P<0.05)。Cox回归模型显示,NSUN2表达是预测ccRCC预后的独立危险因素。结论:NSUN2在ccRCC组织中高表达,且与ccRCC的临床病理特征、预后相关,可作为ccRCC预后判断的指标。Objective:To detect the expression of NOP2/Sun RNA methyltransferase family member 2(NSUN2)in renal clear cell carcinoma(ccRCC)tissue and analyze its relationship with clinicopathological features and prognosis.Methods:A total of 95 ccRCC tissue wax specimens and 95 para-cancer tissue wax specimens were collected.Immunohistochemistry was used to detect the expression level of NSUN2 in the two groups,and the clinicopathological relationship between NSUN2 and ccRCC patients was analyzed.Kaplan-Meier survival analysis,Log-rank univariate analysis and Cox multivariate analysis were used to detect the correlation between NSUN2 expression and prognosis of ccRCC patients.Results:The high expression rate of NSUN2 in cancer tissues was 69.5%,and the high expression rate in para-cancer tissues was 15.8%,the difference between the two groups was statistically significant(P<0.05).The high expression of NSUN2 was related to tumor size,histological grade,lymphatic metastasis and clinical stage(P<0.05).Kaplan-Meier survival analysis and Cox regression model showed that the expression level of NSUN2 was associated with the prognosis of ccRCC.Conclusion:NSUN2 is highly expressed in ccRCC tissues,and is related to the clinicopathological features and prognosis of ccRCC,which could be used as an indicator of prognosis of ccRCC.

关 键 词：肾透明细胞癌 NSUN2 免疫组织化学 表达 预后 

分 类 号：R737.11[医药卫生—肿瘤]