青年型肺腺癌临床特征及驱动基因突变的研究进展  

Advances in clinical features and driver gene mutation of young patients with lung adenocarcinoma

作　　者：孙卓琛 田丰 魏俊 SUN Zhuochen;TIAN Feng;WEI Jun(Department of Thoracic Surgery,Air Force 986 Hospital of Air Force Medical University,Shaanxi Xi'an 710054,China;Department of Thoracic Surgery,Tangdu Hospital of Air Force Medical University,Shaanxi Xi'an 710038,China)

机构地区：[1]空军军医大学第986医院胸外科,陕西西安710054 [2]空军军医大学唐都医院胸外科,陕西西安710038

出　　处：《现代肿瘤医学》2024年第7期1340-1343,共4页Journal of Modern Oncology

基　　金：国家自然科学基金资助项目(编号:81770068)。

摘　　要：近年来,随着低剂量螺旋CT(low-dose CT,LDCT)在肺癌筛查中的应用,越来越多的年轻患者被确诊为肺癌。虽然青年非小细胞肺癌(non-small cell lung cancer,NSCLC)患者(≤45岁)占比较低,但其有独特的临床病理特征及基因突变位点。肺腺癌作为年轻患者中最常见的NSCLC病理类型,其致癌基因改变(genomic alterations,GAs)和临床特征研究较少。随着肺癌个体化治疗观念的提出,其群体研究也逐渐受到重视。因此对青年肺腺癌进行研究极具临床意义。本文就青年肺腺癌患者的发病趋势、病理特征和驱动基因突变等特点作一综述。In recent years,with the use of low-dose CT(LDCT)in lung cancer screening,increasing number of young patients are being diagnosed with lung cancer.Although the proportion of young non-small cell lung cancer(NSCLC)patients(≤45 years old)is low,it has unique clinicopathological features and genetic mutation loci.As the most common pathological type of NSCLC in young patients,lung adenocarcinoma has less research on its oncogenic genetic alterations(GAs)and clinical features.With the concept of individualized treatment of lung cancer,its population studies are gradually gaining attention.Therefore,it is of great clinical importance to study adenocarcinoma of the lung in young adults.In this paper,we review the trends,pathological features and driver mutations in young patients with lung adenocarcinoma.

关 键 词：青年肺腺癌 病理特征 驱动基因突变 

分 类 号：R734.2[医药卫生—肿瘤]