改良格拉斯哥预后评分和全身免疫炎症指数在宫颈癌患者预后预测中的价值  

The value of modified Glasgow prognostic score and systemic immune-inflammation index in predicting the prognosis of cervical cancer patients

作　　者：李玉波[1] 梁俐[2] 吴小娟 田倩 华杨[3] LI Yubo;LIANG Li;WU Xiaojuan;TIAN Qian;HUA Yang(Department of Obstetrics and Gynecology,the Third People's Hospital of Yibin,Sichuan Yibin 644000,China;Department of Gastroenterology,the Third People's Hospital of Yibin,Sichuan Yibin 644000,China;Department of Oncology,the Third People's Hospital of Yibin,Sichuan Yibin 644000,China)

机构地区：[1]宜宾市第三人民医院妇产科,四川宜宾644000 [2]宜宾市第三人民医院消化内科,四川宜宾644000 [3]宜宾市第三人民医院肿瘤科,四川宜宾644000

出　　处：《现代肿瘤医学》2024年第8期1469-1474,共6页Journal of Modern Oncology

基　　金：四川省卫健委科研课题(编号:21PJ541);四川省宜宾市卫健委项目(编号:2019YW010)。

摘　　要：目的:探讨改良格拉斯哥预后评分(mGPS)和全身免疫炎症指数(SII)在宫颈癌患者预后预测中的价值。方法:回顾2010年-2017年我院的宫颈癌患者143例,收集完整病历并随访至2023年6月30日,采用Kaplan-Meier法绘制生存曲线,Log-rank检验和Cox回归分析影响患者预后的因素。结果:患者3年和5年生存率分别为85.31%和66.43%。受试者工作曲线(ROC)显示:mGPS、SII、白蛋白(ALB)、淋巴细胞(LYM)、中性粒细胞(NEU)和C反应蛋白(CRP)预测患者预后的曲线下面积分别为0.821、0.867、0.875、0.885、0.835和0.696,最佳截断值分别为0.5分、34.65 g/L、1.38×10^(9)/L、5.55×10^(9)/L、7.25 mg/L和475×10^(9)/L。Cox回归分析显示:mGPS、SII和FIGO分期是宫颈癌患者预后的影响因素,其HR分别为2.484(GPS=1)、7.096(mGPS=2)、0.121、9.507(FIGO为Ⅲ期)和23.715(FIGO为Ⅳ期)(P<0.05)。结论:mGPS、SII和FIGO分期是宫颈癌患者预后的重要预测因子。Objective:To explore the value of modified Glasgow prognostic score(mGPS)and systemic immune-inflammation index(SII)in predicting the prognosis of patients with cervical cancer.Methods:A retrospective study was conducted on 143 patients with cervical cancer who treated in our hospital from 2010 to 2017.The complete medical records of all patients were collected and the patients were followed up until June 30,2023.Kaplan-Meier method was used to draw survival curves,Log-rank test,and Cox regression analysis were used to identify factors that affect patient prognosis.Results:The 3-year and 5-year survival rates of patients were 85.31% and 66.43%,respectively.The receiver operating curve(ROC)showed that mGPS,SII,albumin(ALB),lymphocytes(LYM),neutrophils(NEU),and C-reactive protein(CRP)were possible influencing factors for predicting the prognosis with area under the curve(AUC)at 0.821,0.867,0.875,0.885,0.835,and 0.696,respectively,with the optimal cut-off values at 0.5 points,34.65 g/L,1.38×10^(9)/L,5.55×10^(9)/L,7.25 mg/L,and 475×10^(9)/L,respectively.Cox regression analysis showed that mGPS,SII,and FIGO stage are prognostic factors for cervical cancer patients,with HR of 2.484(GPS=1),7.096(mGPS=2),0.121,9.507(FIGO stage Ⅲ),and 23.715(FIGO stage IV),respectively(P<0.05).Conclusion:mGPS,SII,and FIGO stage were important prognostic factors for cervical cancer patients.

关 键 词：改良格拉斯哥预后评分 全身免疫炎症指数 宫颈癌 预后 KAPLAN-MEIER法 

分 类 号：R737.33[医药卫生—肿瘤]