干粉吸入剂辅料的研究进展  

Research Progress of Excipients of Dry Powder Inhalation

作　　者：叶永浩 于希 肖颖 陈永奇 YE Yong-hao;YU Xi;XIAO Yin;CHEN Yong-qi(Zhuhai Resproly Pharmaceutical Technology Co.,Ltd.,Zhuhai 519000,China;Faculty of Medicine,Macao University of Science and Technology,Macao 999078,China;State Key Laboratory of Quality Research in Chinese Medicine,Macao University of Science and Technology,Macao 999078,China)

机构地区：[1]珠海瑞思普利医药科技有限公司,广东珠海519000 [2]澳门科技大学医学院,中国澳门999078 [3]澳门科技大学中药质量研究国家重点实验室,中国澳门999078

出　　处：《海峡药学》2024年第2期6-8,共3页Strait Pharmaceutical Journal

基　　金：2020年珠海市产学研珠港澳合作项目(项目编号:ZH22017002200002PWC);2020年珠海市创新创业团队项目(编号:2120004000325)。

摘　　要：干粉吸入剂(DPI)是一种通过肺部给药的制剂,具有生物利用度高、起效快、无首过效应以及无污染等众多优点,在国内外已有多款产品上市销售。干粉吸入剂是吸入制剂的其中一种,属于化学高端制剂,有着巨大的市场潜力。同时其技术壁垒高,开发难度较大,已成为医药行业研究的热点和难点。本文就对干粉吸入剂的辅料研究进展进行归纳和总结,期望为干粉吸入制剂处方开发中辅料的选择提供参考。Dry powder inhalation(DPI)is a preparation that is administered through the lungs.It has many advantages such as high bioavailability,fast onset of action,no first-pass effect,and no pollution.Many products have been marketed at home and abroad.Dry powder inhalation is one of the inhaler preparations,which belongs to the high-end chemical preparations and has huge market potential.At the same time,its high technical barriers and difficult development have become a hot spot and difficulty in pharmaceutical industry research.This paper summarizes the research progress of excipients for Dry powder inhalation,hoping to provide a reference for the selection of excipients in the formulation development of DPI.

关 键 词：干粉吸入剂 辅料 乳糖 亮氨酸 甘露醇 硬脂酸镁 

分 类 号：R94[医药卫生—药剂学]