遗传性结直肠癌的基因阻断  

Genetic blockade in hereditary colorectal cancer

作　　者：陈园园 颜宏利 Yuanyuan Chen;Hongli Yan(Reproductive Medicine Center,the First Affiliated Hospital of Naval Medical University,Shanghai 200433,China)

机构地区：[1]海军军医大学第一附属医院生殖医学中心,上海200433

出　　处：《中华结直肠疾病电子杂志》2024年第1期1-5,共5页Chinese Journal of Colorectal Diseases(Electronic Edition)

基　　金：国家自然科学基金面上项目(No.82273465)。

摘　　要：遗传性结直肠癌的发病率和死亡率呈逐年上升趋势,年轻化为其重要特征。随着肿瘤治疗技术和辅助生殖技术的进步以及患者对生育质量要求的提高,基因阻断可避免遗传性肿瘤基因向下一代传递,已成为该类患者最佳的辅助生育策略选择。本文就遗传性结直肠癌的研究现状和基因阻断方法做一概述,并提出全流程解决方案。该方案亦可借鉴用于其他遗传性肿瘤的基因阻断实践。The incidence and mortality of hereditary colorectal cancer are increasing year by year,and young age of onset is one of its most important features.With the advancement of tumor treatment and assisted reproductive technology and the increased demand of reproductive quality,pathogenic gene blocking is becoming the best strategy for these patients.Here we summarized the research status and specific methods of gene blocking for hereditary colorectal cancer,and proposed the whole-process solutions.Meanwhile,the protocol can also be used as a reference for gene blocking in other hereditary tumors.The incidence and mortality of hereditary colorectal cancer are increasing year by year,and young age of onset is one of its most important features.With the advancement of tumor treatment and assisted reproductive technology and the increased demand of reproductive quality,pathogenic gene blocking is becoming the best strategy for these patients.Here we summarized the research status and specific methods of gene blocking for hereditary colorectal cancer,and proposed the whole-process solutions.Meanwhile,the protocol can also be used as a reference for gene blocking in other hereditary tumors.

关 键 词：结直肠肿瘤 遗传性结直肠癌 基因阻断 辅助生殖 第三代试管婴儿技术 生育力保护 全流程解决方案 

分 类 号：R735.37[医药卫生—肿瘤]