缺血-再灌注损伤促进肝癌复发机制的研究进展  

Research advances in mechanism of the role of ischemia-reperfusion injury in promoting recurrence of hepatocellular carcinoma

作　　者：史亚波 李扬 黄长文 Shi Yabo;Li Yang;Huang Changwen(Nanchang University Medical College,Nanchang 330006,China;Department of Hepatobiliary,Pancreatic and Spleen Surgery,the Sixth Affiliated Hospital of Guangzhou Medical University(Qingyuan People's Hospital),Qingyuan 511500,China)

机构地区：[1]南昌大学医学院,330006 [2]广州医科大学附属第六医院(清远市人民医院)肝胆胰脾外科,广东省清远市511500

出　　处：《中华肝脏外科手术学电子杂志》2024年第1期96-99,共4页Chinese Journal of Hepatic Surgery(Electronic Edition)

摘　　要：肝细胞癌(肝癌)是最常见的原发性肝癌。手术切除、肝移植等外科手段仍是治疗肝癌最有效的治疗方案。术中为了防止出血,阻断肝门部血供是大部分肝癌手术中的必要手段,血流阻断所致的缺血-再灌注损伤(IRI)与肝癌复发密切相关。IRI对于肝癌术后复发的影响主要与活性氧自由基、炎症因子、一氧化氮、热休克蛋白、铁死亡、Kupffer细胞、蛋白酶等多种因素有关。Hepatocellular carcinoma(HCC)is the most common type of primary liver cancer.Surgical resection,liver transplantation and other surgical regimens remain the most effective treatments for HCC.To prevent the intraoperative bleeding,it is necessary to occlude the blood supply at the hilum during most HCC surgeries.Ischemia-reperfusion injury(IRI)caused by blood flow occlusion is intimately associated with the recurrence of HCC.The effect of IRI on postoperative recurrence of HCC is mainly correlated with reactive oxygen species,inflammatory cytokines,nitric oxide,heat shock protein,ferroptosis,Kupffer cells and protease,etc.

关 键 词：癌 肝细胞 复发 缺血-再灌注损伤 活性氧 自由基 炎症因子 热休克蛋白 铁死亡 肠-肝轴 

分 类 号：R735.7[医药卫生—肿瘤]