基于孟德尔随机化探究多发性硬化症与炎症性肠病的双向因果关系  

Bidirectional causal relationship between multiple sclerosis and inflammatory bowel disease based on Mendelian randomization

作　　者：郭文昭 范颖[2] 李笑 吕冠华 GUO Wen-zhao;FAN Ying;LI Xiao;LV Guan-hua(Department of Graduate School,Liaoning University of Chinese Medicine,Shenyang,Liaoning 110847,China;不详)

机构地区：[1]辽宁中医药大学研究生学院,辽宁沈阳110847 [2]辽宁中医药大学中医学院 [3]辽宁中医药大学附属第二医院

出　　处：《现代预防医学》2024年第6期970-973,1023,共5页Modern Preventive Medicine

基　　金：辽宁省名中医传承工作室建设项目(辽中医药发[2022]1号);辽宁中医药大学附属第二医院伯乐工程专项(2022-BLGC-005);辽宁中医药大学附属第二医院育苗工程项目(2023-LZYY-1-25)。

摘　　要：目的探究多发性硬化症(MS)与炎症性肠病(IBD)之间的双向因果关系。方法通过全基因组关联研究(GWAS)汇总数据集,其中MS数据包含14498例样本,IBD数据包含24865例样本,包括溃疡性结肠炎(UC)6968例,克罗恩病(CD)17897例。采用随机效应逆方差加权法(IVW)、加权中位数法(WME)、MR-Egger回归和加权模型进行MR分析。结果发现MS会增加UC的患病风险(IVW:OR=1.108;95%CI:1.012~1.213;P<0.05),但与CD的患病风险无关(IVW:OR=1.021;95%CI:0.926~1.127;P>0.05);UC亦会增加患MS的风险,两者互为因果(IVW:OR=1.096;95%CI:1.027~1.169;P<0.05),且CD会增加患MS的风险(IVW:OR=1.133;95%CI:1.003~1.279;P<0.05)。经MR-Egger回归截距项检验,发现不存在水平多效性(P>0.05);异质性检验结果P值均<0.001,故应重点关注随机效应IVW模型。结论MS会导致患UC的风险升高,而对CD的效应不显著;IBD会增加MS患病风险。Objective To explore the bidirectional causal relationship between multiple sclerosis(MS)and inflammatory bowel disease(IBD).Methods The dataset was pooled by genome-wide association studies(GWAS),of which MS data contained 14498 samples and IBD data contained 24865 samples,including 6968 cases of ulcerative colitis(UC)and 17897 cases of Crohn’s disease(CD).Random effect inverse variance weighting(IVW),weighted median(WME),MR-Egger regression,and weighted model were used for MR Analysis.Results MS was found to increase the risk of UC(IVW:OR=1.108;95%CI:1.012-1.213;P<0.05),but not associated with the risk of CD(IVW:OR=1.021;95%CI:0.926-1.127;P>0.05);UC also increased the risk of MS,and the two were causal(IVW:OR=1.096;95%CI:1.027-1.169;P<0.05),and CD was associated with an increased risk of MS(IVW:OR=1.133;95%CI:1.003-1.279;P<0.05).After the MR-Egger regression intercept item test,it was found that there was no horizontal pleiotropy(P>0.05).The heterogeneity test results were all<0.001,so we should pay more attention to the random effects IVW model.Conclusion MS is associated with an increased risk of UC,but the effect on CD is not significant.IBD increases the risk of developing MS.

关 键 词：多发性硬化症 炎症性肠病 孟德尔随机化 

分 类 号：R744.51[医药卫生—神经病学与精神病学]