连续性肾替代治疗抗菌药物剂量调整专家共识(2024年版)  

Expert consensus on antimicrobial dosing optimization during continuous renal replacement therapy(2024)

作　　者：连续性肾替代治疗抗菌药物剂量调整共识专家组 中国药学会医院药学专业委员会 中国医药教育协会感染疾病专业委员会 卢晓阳[2] 蔡洪流[3] 康焰[4] 俞云松[5] 陈崴[6] 张玉[7] 李璐[2] 王融溶[2] 李佳[8] 李馨[9] 梁培 褚燕琦[11] 俞文桥[3] Expert group of antimicrobial dosing optimization during continuous renal replacement therapy;Chinese Pharmaceutical Association Hospital Pharmacy Professional Committee;Infectious Diseases Society of China;Lu Xiaoyang;Cai Hongliu(不详;Department of Clinical Pharmacy,the First Affiliated Hospital of Zhejiang University,Hangzhou 310003,China;Department of Critical Care Medicine,the First Affiliated Hospital of Zhejiang University,Hangzhou 310003,China)

机构地区：[1]不详 [2]浙江大学医学院附属第一医院临床药学部,杭州310003 [3]浙江大学医学院附属第一医院重症医学科,杭州310003 [4]四川大学华西医院重症医学科 [5]浙江省人民医院感染科 [6]中山大学附属第一医院肾内科 [7]华中科技大学同济医学院附属协和医院药学部 [8]中山大学附属第一医院药学部 [9]吉林大学第二医院药品管理部 [10]南京鼓楼医院药学部 [11]首都医科大学宣武医院药学部

出　　处：《中华肾脏病杂志》2024年第2期158-174,共17页Chinese Journal of Nephrology

摘　　要：连续性肾替代治疗(continuous renal replacement therapy,CRRT)是临床危重症患者重要的治疗手段。危重症患者常常需要同时接受抗菌药物和CRRT治疗。在CRRT期间,抗菌药物的药代动力学和药效学均可能受到影响,目前尚缺乏CRRT期间抗菌药物治疗剂量的推荐和建议。国内临床医学、药学、重症医学以及感染病学专家成立CRRT抗菌药物剂量调整共识专家组,围绕CRRT因素、药物特性、患者因素及CRRT期间各类抗菌药物使用基本原则进行证据检索,并充分讨论,制定了该共识,以期为CRRT期间合理使用抗菌药物提供指导建议。Continuous renal replacement therapy(CRRT)is an important treatment for critically ill patients.Critically ill patients often need to receive antimicrobials and CRRT treatments at the same time.CRRT affects the pharmacokinetics and pharmacodynamics of antimicrobials,and there is a lack of recommendations and suggestions for the antimicrobial dosing during CRRT.The clinical medicine,pharmacy,intensive care and infectious diseases specialists in China set up an expert group on antimicrobial dosing optimization during CRRT,conducted evidence search around CRRT factors,drug characteristics,patient factors and antimicrobial dosing optimization during CRRT,and fully discussed and formulated the consensus,to provide guiding advices on the rational use of antimicrobials during CRRT.

关 键 词：连续性肾替代疗法 危重症护理 抗微生物药物管理 剂量调整 专家共识 

分 类 号：R969.3[医药卫生—药理学]