己唑醇微胶囊悬浮剂的制备与性能研究  

Preparation and properties of hexaconazole microcapsule suspension concentrate

作　　者：肖亚楠 何佩华 李梦蝶 陈乾 金子靖 张念蕾 杨明会 蔡轶恒 张博 XIAO Yanan;HE Peihua;LI Mengdie;CHEN Qian;JIN Zijin;ZHANG Nianlei;YANG Minghui;CAI Yiheng;ZHANG Bo(College of Chemistry and Materials Science,Shanghai Normal University,Shanghai 200234,China;Shanghai Engineering Research Center of Green Energy Chemical Engineering,Shanghai Normal University,Shanghai 200234,China)

机构地区：[1]上海师范大学化学与材料科学学院,上海200234 [2]上海师范大学上海绿色能源化工工程技术研究中心,上海200234

出　　处：《仲恺农业工程学院学报》2024年第1期51-58,共8页Journal of Zhongkai University of Agriculture and Engineering

基　　金：上海市扬帆计划(22YF1431300)。

摘　　要：为了解决己唑醇在使用过程中存在持效期短、利用率低、残留量大以及对目标作物和非靶标生物产生一定毒性等问题,以异佛尔酮二异氰酸酯(Isophorone Diisocyanate, IPDI)为壁材,三乙烯四胺(Triethylenetetramine, TETA)及TETA与乙二胺(Ethylenediamine, EDA)、哌嗪(Piperazine, PIP)、赖氨酸(Lysine, LYS)的混合体系为固化剂,采用界面聚合法制备了4种不同囊壳结构的己唑醇聚脲微胶囊.利用动态光散射、红外光谱、扫描电子显微镜等对制备的聚脲微胶囊进行了表征.结果显示,制备的聚脲微胶囊外观呈球形,粒径分布较均匀,平均粒径约2μm,包封效率在89%~97%,载药量在65%~76%.对4种不同囊壳结构的聚脲微胶囊缓释性能进行研究,在甲醇溶液中,第30 h的累计释放量在29%~65%之间,表明制备的聚脲微胶囊缓释性能良好.缓释速率和累计释放量随着囊壳交联度和链段刚性的增加而降低,表明通过调控囊壳结构可控制微胶囊的缓释行为.本试验利用界面聚合法制备的己唑醇聚脲微胶囊粒径分布均匀,包封效率高,药物负载能力强,缓释性能良好,合成工艺简便,反应条件温和,可为己唑醇微胶囊剂型的研发提供借鉴.In order to solve the problems of short persistence,low utilization efficiency,high residue levels,and certain toxicity to target crops and non-target organisms during the use of hexaconazole,four kinds of hexaconazole polyurea microcapsules with different shell structures were prepared via interfacial polymerization using isophorone diisocyanate(IPDI)as the wall material and a mixture of triethylenetetramine(TETA)and TETA with ethylenediamine(EDA),piperazine(PIP),and lysine(LYS)as the curing agents.The prepared microcapsules were characterized using dynamic light scattering,infrared spectroscopy,and scanning electron microscopy.The results showed that the microcapsules had a spherical shape with a uniform particle size distribution,an average particle size of approximately 2μm,encapsulation efficiency ranging from 89%to 97%,and drug loading ranging from 65%to 76%.The release behaviors of the four different microcapsules were investigated,and the cumulative release rate in methanol solution ranged from 29%to 65%after 30 hours,indicating good sustained-release properties.The sustained release rate and cumulative release amount decreased with increasing crosslinking degree and chain segment rigidity of the microcapsule wall,suggesting that the release behavior of the microcapsules can be controlled by regulating the chain segment structure of the wall.The microcapsules prepared using interfacial polymerization had a uniform particle size distribution,high encapsulation efficiency,strong drug loading capacity,and good sustained-release properties,and the synthesis process was simple as well as the reaction conditions were mild,which could provide a reference for the development of hexaconazole microcapsule formulations.

关 键 词：己唑醇 聚脲 微胶囊 

分 类 号：TQ450.2[化学工程—农药化工]