木犀草素在牙周炎防治中的研究进展  

Research progress of luteolin in the prevention and treatment for periodontitis

作　　者：赵溟昱 时彬冕 谢旭东[1] 许春梅 王骏 ZHAO Mingyu;SHI Binmian;XIE Xudong;XU Chunmei;WANG Jun(State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Department of Periodontics,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)

机构地区：[1]口腔疾病研究国家重点实验室,国家口腔疾病临床医学研究中心,四川大学华西口腔医院牙周病科,四川成都610041

出　　处：《口腔医学》2024年第2期126-129,共4页Stomatology

基　　金：国家自然科学基金面上项目(82071127,82270990);四川省重点研发计划(23ZDYF1722)。

摘　　要：木犀草素是一种植物来源的天然四羟基黄酮类化合物,近年来已被广泛应用于各种炎症相关疾病的研究中,在牙周炎的防治中具有广阔的应用前景,但目前还缺乏木犀草素治疗牙周炎的相关临床试验,其发展潜能、相关作用机制及安全性仍有待进一步探索。本文就木犀草素对牙周炎相关软组织破坏以及牙槽骨吸收的影响进行综述。Luteolin is a natural flavonoid with four hydroxyl groups that originates from plants.It has been extensively investigated in various inflammatory disease models in recent years,and exhibits great application prospect in the prevention and treatment for periodontitis.However,the clinical application of luteolin in periodontitis remains unexplored,and the development potential,underlying mechanisms and safety of luteolin require further investigation.This review will provide a comprehensive overview of the effects of luteolin on soft tissue destruction and alveolar bone loss associated with periodontitis.

关 键 词：木犀草素 牙周炎 炎症反应 牙槽骨吸收 基质金属蛋白酶 

分 类 号：R781.4[医药卫生—口腔医学]