胆红素吸附序贯血液净化疗法对肝衰竭患者的肝功能及凝血功能的影响  

Effect of Bilirubin Adsorption Sequential Blood Purification Therapy on Liver Function and Coagulation Function in Patients with Liver Failure

作　　者：赵晓宁 胡世丽 薛甜甜 ZHAO Xiao-ning;HU Shi-li;XUE Tian-tian(Blood Purification Center,First Affiliated Hospital of Henan University of Science and Technology,Luoyang,Henan,471003,China)

机构地区：[1]河南科技大学第一附属医院血液净化中心,河南洛阳471003

出　　处：《中国血液流变学杂志》2023年第4期556-559,586,共5页Chinese Journal of Hemorheology

摘　　要：目的探讨胆红素吸附序贯血液净化疗法对肝衰竭患者的肝功能及凝血功能的影响。方法将2021年1月—2022年6月在河南科技大学第一附属医院治疗的82例肝衰竭患者,采用随机数字表法分为2组(对照组和观察组)。对照组给予序贯血液净化疗法,观察组在序贯血液净化疗法的基础上给予胆红素吸附疗法,治疗结束后,比较两组患者的肝功能(丙氨酸氨基转移酶,天门冬氨酸氨基转移酶,总胆红素水平)、凝血功能(凝血因子X、凝血酶原活动度、血小板水平)及并发症(置管出血、感染、过敏反应)的发生情况。结果观察组患者肝功能显著改善,丙氨酸氨基转移酶、天门冬氨酸氨基转移酶、总胆红素水平显著低于对照组,且差异有统计学意义(P<0.05);凝血功能显著改善,对照组患者的凝血因子X、凝血酶原活动度、血小板指标显著提高,与观察组患者相比,差异有统计学意义(P<0.05);观察组的并发症(置管出血、感染、过敏反应)的发生情况显著低于对照组(P<0.05)。结论胆红素吸附序贯血液净化疗法在肝衰竭患者中的肝功能凝血功能应用,效果显著,可以显著改善肝功能及凝血功能,减少并发症,值得临床应用推广。Objective To investigate the effect of bilirubin adsorption sequential blood purification therapy on liver function and coagulation function in patients with liver failure.Methods 82 patients with liver failure treated in First Affiliated Hospital of Henan University of Science and Technology from January 2021 to June 2022 were divided into two groups(control group and observation group)using a random number table method.The control group received sequential blood purification therapy,while the observation group received bilirubin adsorption therapy on the basis of sequential blood purification therapy.After treatment,the liver function(alanine aminotransferase,aspartate aminotransferase,total bilirubin levels),coagulation function(coagulation factor X,prothrombin activity,platelet levels)and occurrence of complications(catheter bleeding,infection,allergic reactions)of the two groups of patients were compared.Results The liver function of patients in the observation group was significantly improved.The levels of alanine aminotransferase,aspartate aminotransferase,and total bilirubin were significantly lower than those of the control group,and there was a significant difference(P<0.05).Coagulation function was significantly improved,and coagulation factor X,prothrombin activity and platelet indexes of control group were significantly improved,and compared with observation group,there were significant differences(P<0.05).The incidence of complications(catheter bleeding,infection,allergic reactions)in the observation group was significantly lower than that in the control group(P<0.05).Conclusion Bilirubin adsorption sequential blood purification therapy has a significant effect on liver function and coagulation function in patients with liver failure.It can significantly improve liver function and coagulation function,reduce complications,and is worthy of clinical application and promotion.

关 键 词：胆红素吸附 序贯血液净化疗法 肝衰竭 肝功能 凝血功能 

分 类 号：R575.3[医药卫生—消化系统] R459.5[医药卫生—内科学]